Could Your Brain Microbiome Be Fuelling Cancer Growth?

We used to think the brain was sterile—but research now shows the brain has its own microbiome, just like the gut!

And it’s not just about neurodegenerative diseases like Alzheimer’s; this hidden community of microbes might be fueling brain metastasis too. 🌿🔬

The brain microbiome affects the local environment, potentially promoting inflammation through cells like microglia, and disrupting the blood-brain barrier. This creates pathways for cancer to invade the brain—much like how gut dysbiosis can lead to leaky gut. 🌱🧠

Here are some of the cancers affected by their unique microbiomes:

* Colorectal Cancer

* Pancreatic Cancer

* Breast Cancer

* Lung Cancer

Supporting Evidence:
1. Sampson TR, Mazmanian SK. “Control of Brain Immune Signaling by Gut Microbiota During Health and Disease.” Frontiers in Oncology.2021.
2. Erny D, Hrabě de Angelis AL, Prinz M. “Communications between the Microbiome and the Brain.” Nature Neuroscience. 2020.
3. Zitvogel L, Ma Y, Raoult D, et al. “The Microbiome in Cancer Immunotherapy: Diagnostic Tools and Therapeutic Strategies.” Science. 2021.
4. Feng Y, Hu X, Zhang Y, Wang Y. The Role of Microglia in Brain Metastases: Mechanisms and Strategies. Aging Dis. 2024 Feb 1;15(1):169-185. doi: 10.14336/AD.2023.0514.
5. Lin B, Ye Z, Ye Z, Wang M, Cao Z, Gao R, Zhang Y. Gut microbiota in brain tumors: An emerging crucial player. CNS Neurosci Ther. 2023 Jun;29 Suppl 1(Suppl 1):84-97. doi: 10.1111/cns.14081.
6. Johnson S, Morad G, Ajami N, et al 838 The role of microbiota in metastatic brain tumors Journal for ImmunoTherapy of Cancer 2021;9:doi: 10.1136/jitc-2021-SITC2021.838

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