Ivermectin: From Anti-Parasitic to Potential Anti-Aging Ally?

In the fascinating world of longevity research, even the smallest organisms can unlock big secrets.

Recent studies involving microscopic aquatic creatures called rotifers—excellent models for aging—have shed light on the potential anti-aging effects of ivermectin, a well-known anti-parasitic medication.

Here’s what researchers have discovered:

* 🧬 Enhanced Mitochondrial Efficiency: Ivermectin improved mitochondrial function and bioenergetics, leading to reduced cellular stress.

* 🔄 Activated Protective Pathways: It stimulated autophagy and promoted protein homeostasis, essential processes for cellular health.

* 📉 Reduced Insulin and IGF-1 Levels: Mimicking the effects of fasting, ivermectin lowered insulin and IGF-1, hormones associated with aging.

* 🚫 Inhibited mTOR Pathway: By blocking mTOR, a pathway linked to aging and cancer, it may contribute to longevity.

* 🔥 Modulated Inflammation: Ivermectin dampened chronic low-grade inflammation, targeting neuroinflammation and neurodegeneration associated with aging.

* 🧬 Epigenetic Modulation: It influenced the expression of genes tied to longevity and stress responses.

These intriguing findings highlight why ivermectin has gained attention beyond its traditional use. While more research is needed, the potential for repurposing this medication in anti-aging therapies is exciting.

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Reference:

* Snell TW, Johnston RK, Matthews AB, Zhou H, Gao M, Skolnick J. Repurposed FDA-approved drugs targeting genes influencing aging can extend lifespan and healthspan in rotifers. Biogerontology. 2018 Apr;19(2):145-157. doi: 10.1007/s10522-018-9745-9.

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