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Amos 'n' Andy is an American radio and television sitcom set in Harlem, the historic center of Afro-American culture in New York City. The original radio show, which ran from 1928 to 1960, was created, written and voiced by two white actors, Freeman Gosden and Charles Correll, who played Amos Jones (Gosden) and Andrew Hogg Brown (Correll), as well as incidental characters.

When the show moved to television, black actors took over the majority of the roles; white characters were infrequent. Amos 'n' Andy began as one of the first radio comedy series and originated from station WMAQ in Chicago. After the first broadcast in 1928, the show became a hugely popular radio series.

Early episodes were broadcast from the El Mirador Hotel in Palm Springs, California. The show ran as a nightly radio serial (1928–43), as a weekly situation comedy (1943–55) and as a nightly disc-jockey program (1954–60). A television adaptation ran on CBS (1951–53) and continued in syndicated reruns (1954–66). It would not be shown to a nationwide audience again until 2012