Dr. Byram Bridle about known toxicities of lipid nanoparticles

- 3 different ingredients in the LNPs can potentially cause anaphylactic or allergic reactions
- LNPs can directly cause toxicity in various tissues, especially with repeated dosing: including toxicity in the lungs, the liver, and systemic toxicity
-LNPs are even toxic to cells of the immune system (i.e. macrophages) that play a critical role in promoting vaccine-mediated immune responses
- The latter toxicity counteracts the very immunization effect that is being sought.