100 Million Times More Difficult: Revolutionary Dual Action Antibiotic Makes Bacterial

A groundbreaking study from the University of Illinois Chicago unveils macrolones, a new type of antibiotic that targets bacteria in two ways, drastically reducing the potential for resistance and marking a significant step forward in infectious disease treatment.

A newly discovered antibiotic, which targets two different cellular mechanisms, could make it 100 million times harder for bacteria to develop resistance, according to recent research from the University of Illinois Chicago.

For a new paper in Nature Chemical Biology, researchers probed how a class of synthetic drugs called macrolones disrupt bacterial cell function to fight infectious diseases. Their experiments demonstrate that macrolones can work two different ways – either by interfering with protein production or corrupting DNA structure.