Dr. Byram Bridle on how everyone knew that LNP is toxic

"Dr. Katalin Kariko (co-recipient of Nobel prize): "I would say that mRNA is better suited for diseases where treatment for short treatment is sufficiently curative, so the toxicities caused by delivery materials ( lipid nanoparticles) are less likely to occur"
Everybody who worked for years with these lipid nanoparticles were unanimous and their understanding that you had to minimize the number of doses you were gonna give somebody of these lipid nanoparticles if you were to avoid the toxic effect of these lipid nanoparticles.

Moderna's most advanced competitors, CureVac and BioNTech, have acknowledged the same challenge with mRNA. Each is principally focused on vaccines for infectious disease and cancer, which teh companies believe can be attacked with just a few doses of mRNA.
Why? Because that is the definition of an ideal vaccine. It requires 1 dose at most, maybe 2, maybe 3 doses. If you get 2 or 3 doses, it's not an ideal vaccine, but it still may be close to ideal if it protects a person from getting the disease for the rest of their life. At least it could be close to ideal.
The whole point is they switched the vaccines for infectious disease because they knew if they did function like an ideal vaccine, just a few doses, minimal doses would be required."