Dr. Byram Bridle about LNP-delivery system for modRNAs

- Most people do not realize that the LNP delivery system for modRNAs was switched away from trying to administer drugs and gene therapies precisely because of the definition of an "ideal vaccine"

- It was well recognized that multiple doses of LNPs were dangerous

- Consequently, the concepts of LNP-vectored administration of drug and gene therapies had to be abandoned

- The original hypothesis that drove the use of LNPs as a vaccine delivery technology was that as little as a single dose would be needed if they qualify as an "ideal vaccine"