How AGEs Accelerate Aging: The Science Explained!

5 months ago
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Hey everyone! Welcome back to our channel.
Today, we’re diving into the science behind Advanced Glycation End Products, or AGEs, and how they speed up the aging process.

**What are AGEs?**
AGEs are harmful compounds formed when proteins or fats combine with sugars in the bloodstream. This process is called glycation.

**How Do AGEs Accelerate Aging?**

1. **Protein Cross-Linking**: AGEs cause proteins to become stiff and less functional. This affects your skin, making it less elastic, and can also impact your arteries and organs.

2. **Oxidative Stress**: AGEs generate harmful molecules called reactive oxygen species (ROS), leading to cellular damage and aging.

3. **Chronic Inflammation**: AGEs activate receptors like RAGE, triggering inflammation. Chronic inflammation is a major factor in aging and age-related diseases.

4. **Impaired Cellular Function**: AGEs mess with how your cells work, from signaling to gene expression, making it harder for your body to repair and maintain itself.

5. **Mitochondrial Dysfunction**: AGEs can damage your mitochondria, the powerhouse of your cells, leading to less energy and more damage from ROS.

**Conclusion**
AGEs contribute to aging and various diseases by damaging proteins, increasing oxidative stress, causing inflammation, impairing cellular functions, and disrupting mitochondrial activity.

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