Dr. Zachary Knight: The Science of Hunger & Medications to Combat Obesity

Timestamps
00:00:00 Dr. Zachary Knight
00:02:38 Sponsors: BetterHelp, Helix Sleep & Waking Up
00:07:07 Hunger & Timescales
00:11:28 Body Fat, Leptin, Hunger
00:17:51 Leptin Resistance & Obesity
00:20:52 Hunger, Food Foraging & Feeding Behaviors, AgRP Neurons
00:30:26 Sponsor: AG1
00:32:15 Body Weight & Obesity, Genes & POMC Neurons
00:39:54 Obesity, Genetics & Environmental Factors
00:46:05 Whole Foods, Ultra-Processed Foods & Palatability
00:49:32 Increasing Whole Food Consumption, Sensory Specific Satiety & Learning
00:58:55 Calories vs. Macronutrients, Protein & Salt
01:02:23 Sponsor: LMNT
01:03:58 Challenges of Weight Loss: Hunger & Energy Expenditure
01:09:50 GLP-1 Drug Development, Semaglutide, Ozempic, Wegovy
01:19:03 GLP-1 Drugs: Muscle Loss, Appetite Reduction, Nausea
01:23:24 Pharmacologic & Physiologic Effects; GLP-1 Drugs, Additional Positive Effects
01:30:14 GLP-1-Plus Development, Tirzepatide, Mounjaro, AMG 133
01:34:49 Alpha-MSH & Pharmacology
01:40:41 Dopamine, Eating & Context
01:46:01 Dopamine & Learning, Water Content & Food
01:53:23 Salt, Water & Thirst
02:03:27 Hunger vs. Thirst
02:05:46 Dieting, Nutrition & Mindset
02:09:39 Tools: Improving Diet & Limiting Food Intake
02:14:15 Anti-Obesity Drug Development
02:17:03 Zero-Cost Support, Spotify & Apple Follow & Reviews, YouTube Feedback, Social Media, Neural Network Newsletter