Red Dead Redemption 2 Episode 48: The Fine Art of Conversation

Colonel Favours is redirecting smallpox vaccine away from the Wapiti Reservation to punish the Native Americans for the recent unrest. Monroe requests Arthur's help to steal the vaccine from the army.
Arthur attends a truce meeting between Colonel Favours and Rains Fall, where Rains Fall hopes to negotiate peace.
Arthur and Sadie travel to Hanging Dog Ranch to finish business with the O'Driscolls once and for all.