Nanoscale 3D Mapping Reveals Revolutionary Insights Into Brain Structure

A groundbreaking study has mapped a human cerebral cortex fragment in unprecedented detail, finding crucial cellular details and providing a tool for future research.

Using more than 1.4 petabytes of electron microscopy (EM) imaging data, researchers have generated a nanoscale-resolution reconstruction of a millimeter-scale fragment of human cerebral cortex, providing an unprecedented view into the structural organization of brain tissue at the supracellular, cellular, and subcellular levels. The human brain is a vastly complex organ and, to date, little is known about its cellular microstructure, including the synaptic and neural circuits it supports. Disruption of these circuits is known to play a role in myriad brain disorders.