Cancer risk assessment, its wretched history and its impact on public health | Prof Edward Calabrese

The linear no-threshold (LNT - https://www.nuclear-power.com/nuclear-engineering/radiation-protection/radiobiology/linear-no-threshold-model/) single-hit dose response model for cancer risk assessment is assessed with respect to its historical foundations.

How did mistakes, ideological biases, and scientific misconduct by key scientists affect the acceptance, validity, and applications of the LNT model for cancer risk assessment. In this discussion, Prof Calabrese demonstrates that the LNT single-hit model was inappropriately adopted for governmental risk assessment, regulatory policy, practices, and risk communication.

Edward J. Calabrese is a Professor of Toxicology at the University of Massachusetts, School of Public Health and Health Sciences, Amherst. Dr. Calabrese has researched extensively in the area of host factors affecting susceptibility to pollutants, and is the author of over 1,000 papers in scholarly journals, as well as more than 10 books. Dr. Calabrese was awarded the 2009 Marie Curie Prize for his body of work on hormesis (https://link.springer.com/chapter/10.1007/978-1-4020-6869-0_2 ). He was the recipient of the International Society for Cell Communication and Signaling-Springer award for 2010. He was awarded an Honorary Doctor of Science Degree from McMaster University in 2013. In 2014 he was awarded the Petr Beckmann Award from Doctors for Disaster Preparedness. Dr. Calabrese was awarded the G. William Morgan Lectureship Award and the Roberts S. Landauer, Sr., Lectureship Award in 2022 from the Health Physics Society.

Links:
Interview on Hormesis - https://www.youtube.com/watch?v=v9xgMPNizTQ

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Presentation: 28 February 2024