Is Cannabis Killing Your Balls?

9 months ago
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Citation:
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Farkas, I., Kalló, I., Deli, L., Vida, B., Hrabovszky, E., Fekete, C., ... & Liposits, Z. (2010). Retrograde endocannabinoid signaling reduces GABAergic synaptic transmission to gonadotropin-releasing hormone neurons. Endocrinology, 151(12), 5818-5829. https://academic.oup.com/endo/article-abstract/151/12/5818/2456296

Wenger, T., Ledent, C., Csernus, V., & Gerendai, I. (2001). The central cannabinoid receptor inactivation suppresses endocrine reproductive functions. Biochemical and biophysical research communications, 284(2), 363-368. https://www.sciencedirect.com/science/article/abs/pii/S0006291X01949770

Kolodny, R. C., Masters, W. H., Kolodner, R. M., & Toro, G. (1974). Depression of plasma testosterone levels after chronic intensive marihuana use. New England Journal of Medicine, 290(16), 872-874. https://www.nejm.org/doi/full/10.1056/NEJM197404182901602

List, A. L. A. N., Nazar, B. A. R. R. Y., Nyquist, S. A. L. L. Y., & Harclerode, J. A. C. K. (1977). The effects of delta9-tetrahydrocannabinol and cannabidiol on the metabolism of gonadal steroids in the rat. Drug Metabolism and Disposition, 5(3), 268-272. https://realmofcaring.org/wp-content/uploads/2019/10/The-effects-of-delta9-tetrahydrocannabinol-and-cannabidiol-on-the-metabolism-of-gonadal-steroids-in-the-rat.pdf

Thistle, J. E., Graubard, B. I., Braunlin, M., Vesper, H., Trabert, B., Cook, M. B., & McGlynn, K. A. (2017). Marijuana use and serum testosterone concentrations among US males. Andrology, 5(4), 732-738. https://onlinelibrary.wiley.com/doi/full/10.1111/andr.12358

Dixit, V. P., Gupta, C. L., & Agrawal, M. (1977). Testicular degeneration and necrosis induced by chronic administration of cannabis extract in dogs. Endokrinologie, 69(3), 299-305. https://europepmc.org/article/med/913356

Dixit, V. P., Sharma, V. N., & Lohiya, N. K. (1974). The effect of chronically administered cannabis extract on the testicular function of mice. European journal of pharmacology, 26(1), 111-114. https://www.sciencedirect.com/science/article/pii/0014299974900818

Mandal, T. K., & Das, N. S. (2010). Testicular toxicity in cannabis extract treated mice: association with oxidative stress and role of antioxidant enzyme systems. Toxicology and industrial health, 26(1), 11-23. https://journals.sagepub.com/doi/abs/10.1177/0748233709354553

Said, T. M., Agarwal, A., Sharma, R. K., Mascha, E., Sikka, S. C., & Thomas Jr, A. J. (2004). Human sperm superoxide anion generation and correlation with semen quality in patients with male infertility. Fertility and sterility, 82(4), 871-877. https://www.sciencedirect.com/science/article/abs/pii/S001502820401101X

Alagbonsi, I. A., Olayaki, L. A., & Salman, T. M. (2016). Melatonin and vitamin C exacerbate Cannabis sativa-induced testicular damage when administered separately but ameliorate it when combined in rats. Journal of basic and clinical physiology and pharmacology, 27(3), 277-287. https://www.degruyter.com/document/doi/10.1515/jbcpp-2015-0061/html

Succu, S., Mascia, M. S., Sanna, F., Melis, T., Argiolas, A., & Melis, M. R. (2006). The cannabinoid CB1 receptor antagonist SR 141716A induces penile erection by increasing extra-cellular glutamic acid in the paraventricular nucleus of male rats. Behavioural brain research, 169(2), 274-281. https://www.sciencedirect.com/science/article/abs/pii/S0166432806000684

Melis, M. R., Succu, S., Mascia, M. S., Sanna, F., Melis, T., Castelli, M. P., & Argiolas, A. (2006). The cannabinoid receptor antagonist SR-141716A induces penile erection in male rats: involvement of paraventricular glutamic acid and nitric oxide. Neuropharmacology, 50(2), 219-228. https://www.sciencedirect.com/science/article/abs/pii/S0028390805003527

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