Prime Medicine awarded $15M from Cystic Fibrosis Foundation to advance gene editing technology
3 months ago
1
Hotspot editing uses a small number of Prime Editors to address multiple mutations at mutational hotspots. make smaller corrections to specific CFTR mutations. Preclinical data suggest that using only eight hotspot Prime Editors could benefit over 98 percent of all people with CF. Prime Medicine has already begun to use hotspot to correct the G542X nonsense CFTR mutation in the lab and will extend this work to develop therapies for other clusters of CFTR mutations.
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