Microbubble Shell Physicochemical Properties on Ultrasound-Mediated Drug Delivery to the Brain

MICROBUBBLES ARE FOUND IN SPRING WATER, FOODS AND BEVERAGES.

This presentation is focused on the effects of microbubble shell physicochemical properties on ultrasound-mediated drug delivery to the brain.

Lipid-shelled microbubbles have been used in ultrasound-mediated drug delivery for some time now. The physiological and chemical properties of microbubble shell and how this affects delivery efficacy when determining the microbubble mechanical properties, circulation persistence, and dissolution behavior during cavitation.

The aim of this study was to investigate the shell effects on drug delivery efficiency in the brain via blood-brain barrier (BBB) opening in vivo using monodisperse microbubbles with different phospholipid shell components and longer acyl chains.

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