Prof. Fuhua Yang #2 @ FLOGEN SIPS 2022 Yoshikawa Intl. Symposium on Oxidative Stress

FLOGEN SIPS 2022: Yoshikawa International Symposium on Oxidative Stress for Sustainable Development of Human Beings (2nd international Symposium)Show more

Presenter:
Prof. Fuhua Yang, Division of Anti-Oxidant Research, Gifu University, Gifu, Japan

Title:
Involvement of anti-oxidant Twendee X in immunity.

Abstract
Many diseases and physical disorders are caused by both external and internal factors, but the common denominator is inflammation and oxidative stress. Oxidative stress is elevated in people infected with COVID-19, which has recently become an urgent problem. Suppressing oxidative stress on a daily basis and maintaining a high level of self-immunity can help prevent and treat disease and maintain good health.
Intestines are involved in about 60% of our immune system. There are over 100 species of, or 100 trillions of bacteria in our intestines, and their ideal balance is 20% of good, 10% of bad, and 70% of opportunistic bacteria. This balance is lost by disturbed life rhythm and various diseases, in other words “oxidative stress”, being said to decrease bacterial diversity. Reducing oxidative stress and increasing diversity of intestinal bacteria is important for maintaining healthy life. Composed of vitamins, CoQ10, and amino acids, Twendee X (TWX) is an antioxidant which is confirmed to have a dementia-prevention effect. Effects of increased bacterial diversity and NK activity by administration of TWX was examined.
Rats were given an antifungal agent OPP for 2 weeks, then blood and feces samples were collected to analyze blood oxidative stress and intestinal bacterial diversity. TWX was administrated from 1 week before OPP initiation. In addition, we measured the NK activity of TWX in normal mice and compared it with the mice without any treatment. Furthermore, a questionnaire survey for 57 healthy participants was conducted to compare their defecation status and intestinal microbial flora between before and after one month TWX administration.
Although OPP rat group increased blood oxidative stress by 5%, no significant change was observed in microbial flora diversity. A rat group given TWX since 1 week before decreased oxidative stress by 13.3% and increased bacterial diversity 1.5 times higher, compared to rats which wasn’t given, and the number of Akkermansia, anti-inflammatory bacteria, was increased 3.5 times more. Furthermore, administrating TWX to healthy mice increased their NK activity twice as high as that of untreated mice. In the questionnaire survey for healthy participants who were given TWX for 1 month, the number of good bacteria and intestinal bacterial diversity were increased. Their defecation status and QOL were improved with that.
TWX tends to reduce oxidative stress, to increase the number of bacteria and diversity in intestinal microflora, and to enhance NK activity known as a tumor immunity. It was suggested that this enables to protect human body from harmful substances invaded inside, improve immune system, and improve daily defecation status and QOL.

References:

1. Novel compositions and uses thereof WO 2008071790 A3

2. Antioxidant composition and its use in diabetes EP 1932542 A1

3. Composition for accelerating alcohol metabolism and for reducing the risk of alcohol induced diseases WO 2012095509 A8

4. Composition for moderating triglyceride and cholesterol levels WO 2009062910 A1