Prof. Jun-Jie Zhu @ FLOGEN SIPS 2022 Yoshikawa Intl. Symposium on Oxidative Stress
FLOGEN SIPS 2022: Yoshikawa International Symposium on Oxidative Stress for Sustainable Development of Human Beings (2nd international Symposium)
Presenter:
Prof. Jun-Jie Zhu, Nanjing University, Nanjing, China
Title:
DNA Nano Self-assemblies for the Application in Cancer Diagnosis and Therapy
Abstract
Cancer is a conundrum in modern medicine and has become a serious threat to human health and life [1], thus the the early diagnosis and precise therapy are crucial to improve the cancer cure rates [2]. Taking advantage of the DNA nanotechnology, an RNA aptamer-based near-infrared gated nanodevice for low-background imaging of mRNA in living cells have been first developed based on the fluorescence enhancement property of RNA aptamer and the catalytic hairpin assembly reaction-mediated signal amplification strategy. Subsequently, DNA nanocarrier with excellent biological stability, strong enzymatic resistance and collaborative drugs delivery is constructed by functionalized circular DNA, which can effectively combat the multidrug-resistant human leukemia. Moreover, a multifunctional DNA-Au nanomachine integrating both diagnostic and therapeutic agents is proposed, which can be triggered by the endogenous mRNA, leading to the activation of multi-mode synergistic therapy and in situ imaging. These researches conducive to the accurate diagnosis and image-guided precise treatment of cancers, which may provide a new route for the construction of intelligent responsive theranostic nanoplatform.
References:
[1] H. Dong, J. Lei, L. Ding, Y. Wen, H. Ju, X. Zhang, Chem. Rev. 113 (2013) 6207.
[2] X. Zhang, Z. Xi, J. O. Machuki, Y. Yang, L. Zhang, J. Tian, K. Guo, Y. Yu, F. Gao, ACS Nano 13 (2019), 5306.
-
13:41
JoBlo Horror Originals
22 hours agoWhat Happened To Seed Of Chucky?
22.9K3 -
6:36
ParisDemers
21 hours agoHugh Jackman’s Secret To Getting RIPPED For DEADPOOL 3 At 54 (Diet Hack)
16K2 -
12:08
Space Ice
18 hours agoTenet Is So Good WoW dooG oS sI teneT - Best Movie Ever
12.5K14 -
10:56
shaneandliana
16 hours agoRITUAL Sacrifice Scare Prank On Brother * CRAZY REACTION*
21.4K1 -
3:37:05
Alex Zedra
11 hours agoLIVE! Playing Call of Duty!
48.9K32 -
3:47
Michael Heaver
1 day agoAmericans Give OVERWHELMING Verdict
12.1K27 -
37:03
ROSE UNPLUGGED
22 hours agoThe Real Truth About the Border: From One Who Knows
9.82K3 -
44:28
LSNTV
18 hours agoWhat you NEED to Know About Last Night's Trump-Biden Debate
9.68K8 -
37:46
TheMonicaCrowleyPodcast
18 hours agoThe Monica Crowley Podcast: Controlled Demolition
6.34K7 -
8:46:10
SNEAKO
19 hours agoSNEAKO & JAKE SHIELDS: POWERSLAP TAKEOVER!
173K39