Unanticipated Complications with mRNA Vaccine

The principle of the unknown unknowns comes to bear with this paper. It seems the Pfizer vaccine can cause formation of abnormal proteins, not anticipated by the mRNA template.

N1-methylpseudouridylation of mRNA causes +1 ribosomal frameshifting
https://www.nature.com/articles/s41586-023-06800-3

Morais, Pedro, Hironori Adachi, and Yi-Tao Yu. "The critical contribution of pseudouridine to mRNA COVID-19 vaccines." Frontiers in cell and developmental biology 9 (2021): 3187.
https://www.frontiersin.org/articles/10.3389/fcell.2021.789427/full

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