SPIDER-MAN 2 | PS5 EXCLUSIVE | PART 1 INTRODUCTION | FULL GAMEPLAY

Plot
Peter starts his first day as a physics teacher with Miles among his students, but they are interrupted by an attack by Sandman, requiring both of them to subdue him. Peter is fired for abandoning the class and returns to his Aunt May's home in Queens, which he has moved into following her death,[a] to meet with his girlfriend Mary Jane. They are surprised to see their old friend Harry, who has miraculously recovered from his terminal illness. Harry offers to hire Peter to work at his new startup, the Emily-May Foundation (EMF), so they can "heal the world". Concurrently, Miles struggles to write his college application essay and learns his mother Rio has begun dating.

While overseeing a transfer of some of the Raft's inmates, Peter and Miles witness an attack by Kraven the Hunter and his forces, who capture Scorpion and Martin Li. While investigating Kraven, Peter discovers he is capturing super-powered individuals to hunt them for sport. Having already killed Scorpion, Vulture, Shocker, and Electro, Kraven attempts to capture Felicia Hardy; Miles protects her and helps her escape to Paris. While visiting Coney Island to reconnect, Peter, Mary Jane, and Harry witness Kraven's hunters attack the park to capture Tombstone. While rescuing civilians caught in the crossfire, Harry learns about Peter's double life and reveals he was cured by Curt Connors via an organic exosuit that physically augments his body.

With his powers rapidly developing, Harry helps Peter rescue Tombstone while Mary Jane discovers that Kraven has kidnapped Connors. The trio attempt to save Connors, but are unable to stop Kraven from forcibly turning him back into the Lizard. Connors escapes while Kraven mortally wounds Peter, who is saved when Harry's exosuit transfers itself to his body. After Peter confronts Kraven with his newly enhanced powers, the latter develops an interest in hunting him personally.

After Peter and Harry synthesize an antidote for Connors, the former locates Connors with Miles's help and eventually defeats and cures him. Upon seeing Peter wearing the exosuit, Connors explains it is actually an alien called a symbiote that Oscorp obtained years prior and warns him to destroy it. Under the symbiote's corrupting influence, Peter refuses and keeps it for himself despite learning Harry's illness returned, fracturing their friendship. Meanwhile, Kraven captures Miles and forces him to fight Li to the death. Overcoming his anger towards Li for killing his father,[a] Miles helps him escape and directs him to find Peter. Once Li informs him of Miles's location, Peter arrives to rescue him and nearly kills Kraven before Miles intervenes and convinces Peter to remove the symbiote.

Peter takes the symbiote to Oscorp to destroy it, but a desperate Harry intercepts him and reclaims it, transforming him into Venom. Venom escapes, overpowers and kills Kraven, and convinces Harry to "heal the world" by infecting it with symbiotes, starting with New York. Mary Jane falls victim and is transformed into Scream, but Peter helps her break free. As Peter and Miles attempt to stop the symbiote invasion, the former is debilitated by a trace amount of Venom's symbiote still in him, but Miles and Li help tame it and convert it into the Anti-Venom symbiote, which can destroy other symbiotes. Concurrently, Venom recovers the meteorite that originally brought him to Earth to enhance his powers and accelerate his invasion. Peter and Miles distract Venom while Mary Jane steals the meteorite and destroys it with the EMF's particle accelerator, destroying Venom's spawn while Peter kills Venom at Harry's insistence.

In the aftermath, Harry is rendered comatose, prompting his enraged father, Norman, to prepare the "G-serum". Mary Jane quits her job to run her own podcast and moves in with Peter, who opts to take a break from being Spider-Man to focus on rebuilding the EMF, trusting Miles to protect the city as Spider-Man. In a mid-credits scene, Norman visits an imprisoned Otto Octavius to demand the Spider-Men's secret identities, blaming them for Harry's condition. Octavius refuses, taking glee in Norman's suffering as he writes his "final chapter". In a post-credits scene, Miles completes his essay and meets Rio's new boyfriend, Albert Moon, who introduces them to his daughter Cindy.