SPIDER-MAN_REMASTERED | PART 1 INTRODUCTION | FULL GAMEPLAY LONGPLAY WALKTHROUGH

Plot
Following the capture of Wilson Fisk by Spider-Man, a masked gang known as the Inner Demons begins seizing Fisk's illicit assets. Mary Jane and Spider-Man learn that the Demons are seeking something called Devil's Breath. With the aid of Officer Jefferson Davis, Spider-Man thwarts a Demon attack. Davis is lauded for his heroism at a re-election event for Mayor Norman Osborn. The Demons attack the event, killing Davis and many other attendees. Peter witnesses Martin Li transforming into their leader, Mister Negative, but is knocked unconscious before he can intervene. Following the attack, Osborn hires Silver Sablinova and Sable International to supplant the police. Peter befriends Davis' son, Miles Morales, and persuades him to volunteer at F.E.A.S.T.

Peter and Otto Octavius continue their research into advanced prosthetic limbs, but Osborn withdraws their funding in an attempt to force Octavius to work for his mega-corporation Oscorp. While searching for Li, Spider-Man discovers that Devil's Breath is a lethal, virulent bioweapon inadvertently created by Oscorp while developing a cure for genetic diseases. Li locates and steals the only sample of Devil's Breath and threatens to release it unless Osborn surrenders to him. Mary Jane and Spider-Man foil Li, who is subsequently incarcerated at a nearby maximum-security prison called the Raft, while the Devil's Breath is secured.

Meanwhile, Octavius obsesses over creating enhanced limbs that exceed the human body's limitations, creating four mechanical tentacles operated from his back and mentally controlled via a neural interface. He reveals to Peter that he is suffering from a neuromuscular disease that will inevitably immobilize him and that enhanced limbs will allow him to continue his work when his body fails. Peter warns Octavius that the interface could impact his mind and personality. Octavius continues its use in secret, overcome with anger at Osborn. While investigating a breakout at the Raft, Spider-Man learns that some of his greatest enemies—Li, Electro, Vulture, Rhino, and Scorpion—have escaped. They subdue Spider-Man and present him to Octavius, now "Doctor Octopus", who warns the beaten Spider-Man not to interfere before retaking the Devil's Breath and releasing it in Times Square, causing a mass outbreak that infects numerous people, including Aunt May. New York descends into chaos while Octavius' team attacks the city. Osborn declares martial law and blames Spider-Man for the incident, branding him a fugitive.

Spider-Man gradually takes back the city, defeating Electro, Vulture, Rhino, and Scorpion. Mary Jane infiltrates Osborn's penthouse and learns that Oscorp developed Devil's Breath to cure Osborn's terminally ill son Harry. As a child, Li was a test subject for the cure, gaining his abilities in an explosion of energy that also killed his parents and caused his hatred for Osborn. She also learns that an antidote for Devil's Breath exists and that Li has stolen it. Spider-Man tracks down and defeats Li, but Octavius arrives, brutalizes Spider-Man, and escapes with the antidote and Osborn. While Spider-Man recovers, Miles is bitten by an Oscorp genetically modified spider that Mary Jane unknowingly carried from Osborn's penthouse.

Wounded, Peter builds himself an armored suit and confronts Octavius atop Oscorp Tower, rescuing Osborn. Octavius reveals that he knows Peter's secret identity and a battle ensues. Spider-Man retrieves the antidote and defeats Octavius, leaving him to be arrested. Peter is forced to choose between using the limited cure to save May from her imminent death or synthesizing a vaccine for the infected masses; he decides to save everyone. Before she dies, May reveals that she knows he is Spider-Man and is proud of him.

Three months later, New York has returned to normal, and Peter and Mary Jane rekindle their relationship. Miles reveals to Peter that he has gained spider-like powers, prompting Peter to reveal his own. Having resigned as mayor in disgrace, Osborn enters a secret laboratory where Harry is kept in stasis with a black, web-like substance. As Osborn places his hand on the tank, the substance reacts and copies him.