Om mani padme hum

Sanskrit Mantra. ཨོཾ་མ་ཎི་པདྨེ་ཧཱུྃ.
The precise meaning and significance of the words remains much discussed by Buddhist scholars. The literal meaning in English has been expressed as "praise to the jewel in the lotus", or as a declarative aspiration possibly meaning "I in the jewel-lotus". Padma is the Sanskrit for the Indian lotus, and mani for "jewel", as in a type of spiritual "jewel" widely referred to in Buddhism. The first word, aum/om, is a sacred syllable in various Indian religions, and hum represents the spirit of enlightenment.

There are a lot of different meanings and different opinions on what each syllable means.
Generally, each syllable represents one of the six goals of Buddhist existence and helps heal or purify and bring forth the positive qualities associated with that goal.

• Om = the vibration or sound of the universe; represents divine energy and generosity and purifies the ego
• Ma = represents ethics and purifies jealousy
• Ni = represents patience and purifies want or desire
• Pad = represents diligence and purifies ignorance and judgment
• Me = represents concentration and purifies attachment
• Hum = the unity of all; represents wisdom and purifies hatred