NADIR ALI 4’ | Study 28k people: PCSK9 inhibitor… No mortality benefit

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presents episode 1124 | Dr Nadir Ali
Low Carb Denver podcast

Animal studies: using PCSK9 inhibitor-like approach
results: higher risk of diabetes & visceral obesity &
higher fat in heart
WHY? It removes LDL receptor in liver & pancreas, that was
sucking up LDL from bloodstream...
LDL particle is not just cholesterol filled,
but is fat filled, so: more receptors &
fat is removed from circulation, giving
fatty liver & fatty pancreas

People born with PCSK9 DEFICIENCY: they have higher risk:
-diabetes; higher weight; more visceral obesity
Fourier PCSK9 trials, 28k patients: half control; half: Repatha
results: Repatha group dropped LDL: to 30mg/dL [.8 mmol/L]
Control: 90mg/dL
OUTCOME: no mortality difference!
"Abject failure of the drug"
SUM: PCSK9 inhibitor: higher risk
-diabetes, visceral obesity
Human genetic trials: same result
"Do not tell patients this drug beneficial"

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Original Youtube: https://youtu.be/6YLrW-390wI?si=j7Fg7lTKxJ3Fsn5n
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