2 years ago

162

*THIS is Episode 4* - _Protecting the Side-Chains and a Longtime Chemist Friend - Dr. Bruce Lipshutz, Part 01_
Ep 1: https://youtu.be/4rwPi1miWu4
Ep 2: https://youtu.be/aUOZh4zmrXo
Ep 3: https://youtu.be/v3A8_ezYlZY
Ep 5: https://youtu.be/t5PfBzQUjW8
Ep 6: https://youtu.be/ZtitTE2BavU
Ep 7: https://youtu.be/cL0NIFk1grE
Ep 8: https://youtu.be/atxmIZw3DdA
*Episode 9 premieres soon! SUBSCRIBE so you'll be notified!*

Something definitely is in the water, and it’s not condensation reactions, but zwitterions. After observing the incorrect reference implying that Cronin’s oligopeptides formed in water, Dr. Tour corrects the record and shows how the reference demands quite the opposite—a dry, 130°C furnace for 15 hours. Reading beyond just the title of the paper, we see agreement from Lee Cronin as well—thermodynamic equilibrium shifts the reaction, not towards polypeptides, but back to amino acids. The “YouTube professor” was wrong again. We then meet Dr. Bruce Lipshutz, a friend of Dr. Tour, who also agrees with Tour, and in his synthesis, he uses hydrophobic pockets to remove the synthesis from occurring in water, while also adding human-made protecting groups to the amines to remove free amino acids and its active sidechains. With the YouTuber’s erroneous claim of peptide synthesis in water not being a problem now clearly exposed, Dr. Tour summarizes how Dr. Lipshutz’s experiment was not actually a showing of amino acid coupling in water at all, but a demonstration of the need to protect side-chains of the amines and esterify the carboxyl groups, which loaded the system for the chemistry to work—something early Earth could not enjoy.

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Check out all our episodes:
*Addressing Abiogenesis, Season 2*
https://youtube.com/playlist?list=PLILWudw_84t22BWvWsoXCmaXNllbfJ2h7

*Addressing Abiogenesis, Season 1*
https://youtube.com/playlist?list=PLILWudw_84t2THBvJZFyuLA0qvxwrIBDr

VIDEO INDEX
00:00 Dilation of a YouTuber's Initiative
01:32 Email Unraveling
03:26 Cronin on Peptide Synthesis in Water
06:31 Look Beyond the Title
07:50 YouTuber Brings on Bruce Lipshutz
10:48 Review: Amino Acids, Peptides & Synthesis
13:38 Bruce's Paper & Where the Chemistry Happens
14:49 Game Over — Waterworld 2-2
15:07 Attacking Amino Acid's Zwitterions
17:21 Not Amino Acid Coupling
18:56 No Active Sidechains
19:15 System: Totally Loaded
19:20 Summary
20:31 Misquoting, Twisting & Lying, He Says
20:59 Next Time: Bruce Lipshutz Part 02