Premium Only Content

How Do Erectile Dysfunction Drugs Work? A Complete Rundown on PDE5 Inhibitors
If you’ve searched online for information about treating ED, you’ve likely heard of medications called PDE5 inhibitors.
PDE5 inhibitors are medications that improve blood flow to certain tissues, including the tissue of the penis. They work by inhibiting the action of phosphodiesterase-5, an enzyme that can be found in the smooth muscle cells of blood vessels.
Although PDE5 inhibitors were originally designed to treat cardiovascular health issues, they’re most commonly used today to treat erectile dysfunction.
Common PDE5 inhibitors available today include Viagra® (which contains the active ingredient sildenafil), Cialis® (tadalafil), Levitra® (vardenafil) and Stendra® (avanafil).
Below, we’ve explained what PDE5 inhibitors are, how they work and how you might be able to use them to treat ED.
We’ve also discussed several important topics related to PDE5 inhibitors, from side effects and interactions to frequently asked questions and more.
-
1:01:07
VINCE
2 hours agoINCOMING! Trump Set To Reveal The Deep State's Darkest Secrets TODAY | Episode 87 - 07/17/25
164K113 -
LIVE
The Big Mig™
3 hours agoPOLITICAL FIRESTORM: DOJ FIRES Federal Prosecutor Maurene Comey
5,293 watching -
LIVE
LFA TV
15 hours agoLFA TV ALL DAY STREAM - THURSDAY 7/17/25
4,979 watching -
1:11:30
Dear America
3 hours ago1 MILLION Illegals Have “Self-Deported”!! IT’S WORKING!! + Trump Calls Epstein List a HOAX?!
88.4K119 -
LIVE
Badlands Media
5 hours agoBadlands Daily: July 17, 2025
5,451 watching -
LIVE
Wendy Bell Radio
6 hours agoMAGA Wants REVENGE
8,786 watching -
2:04:57
Matt Kohrs
11 hours agoMARKET OPEN: Bounce or Bust?! || Live Trading
16.3K3 -
59:06
The Mike Schwartz Show
3 hours agoTHE MIKE SCHWARTZ SHOW with DR. MICHAEL J SCHWARTZ 07-17-2025
10.3K -
4:03
Blackstone Griddles
16 hours agoBlackstone Smokeless Fire Pit Overview | Blackstone Griddles
6.17K1 -
15:48
Professor Gerdes Explains 🇺🇦
22 hours agoDecoding the Battlefield: What Actual Combat Says About Russia and Ukraine
3.68K2