San Francisco 49ers vs New York Giants Prediction and Picks - Free NFL Expert Pick for 9-21-23

If you are looking for NFL football picks and predictions for the Week 3 NFL matchup between the San Francisco 49ers and New York Giants, we have you covered! Our NFL football handicapping experts discuss the opening weekend from a sports betting perspective, sharing their picks and predictions vs. the current odds.

#nflpicks #nflpredictions #nflbetting

San Francisco 49ers vs New York Giants Betting Preview

Thursday, September 21, 2023

8:15 PM ET

Levi's Stadium, Santa Clara, CA

TV: Amazon Prime Video

Radio: 49ers: 107.7 FM | Giants: 98.7 FM

Online: Amazon Prime Video

Spread: 49ers -10.5

Total: 45.5

Interesting Facts:

The 49ers and Giants are two of the most storied franchises in the NFL, with a combined 11 Super Bowl titles.
The two teams have met 17 times in the playoffs, with the 49ers leading the all-time series 10-7.
The 49ers are coming off a thrilling win over the Seattle Seahawks in Week 1, while the Giants lost to the Tennessee Titans.
The 49ers are led by quarterback Brock Purdy, who is in his second season as the team's starter.
The Giants are led by quarterback Daniel Jones, who is entering his fourth season with the team.
Team Twitter Hashtags:

#49ers
#Giants

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