Lions Mane and Brain Health

In this video, Dr. Goel discusses the fascinating benefits of Lion's Mane, a functional mushroom that has gained popularity for its potential impact on brain health.
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Join Dr. Goel as he delves into the science behind Lion's Mane and explores studies related to neurogenesis, immunomodulation, and anti-tumor properties. Discover how Lion's Mane has been used for centuries in Chinese medicine and its association with various health benefits. Dr. Goel highlights key research findings, including studies on Alzheimer's and Parkinson's diseases, metabolic improvements, and more. While most of the evidence comes from animal studies, there is one human trial that showcases promising results. Get ready to expand your knowledge about Lion's Mane and stay tuned for the next episode, where Dr. Goel will explore the hype surrounding Cordyceps. Don't forget to check the show notes for links to the studies mentioned.
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TIMESTAMP
0:00 - Introduction
0:15 - Dr. Goel introduces the topic of Lion's Mane
1:02 - Overview of Lion's Mane and its historical use
1:43 - Focus on brain health and its association with Lion's Mane
2:54 - Other potential benefits of Lion's Mane
3:08 - Specific use in neurodegenerative diseases
3:44 - Study 1: Reduction of cerebral amyloid beta plaque in mice
4:26 - Study 2: Improved function in mice with Alzheimer's
4:47 - Study 3: Neuroprotective properties in rats
5:27 - Study 4: Human trial showing improvement in cognitive ability
6:12 - Mention of other studies related to immune and cancer function
6:47 - Summary of neuroprotective and neurogenesis effects
7:04 - Mention of immuno-modulatory and anti-tumor effects
7:57 - Conclusion

Studies -

https://pubmed.ncbi.nlm.nih.gov/27350344/ - Tsai-Teng T, Chin-Chu C, Li-Ya L, Wan-Ping C, Chung-Kuang L, Chien-Chang S, Chi-Ying HF, Chien-Chih C, Shiao YJ. Erinacine A-enriched Hericium erinaceus mycelium ameliorates Alzheimer's disease-related pathologies in APPswe/PS1dE9 transgenic mice. J Biomed Sci. 2016 Jun 27;23(1):49. doi: 10.1186/s12929-016-0266-z. PMID: 27350344; PMCID: PMC4924315.

erinocenes have anti dementia effects - Study by Tsai-teng et al. investigating therapeutic potential and anti dementia activity of Hericium erinaceus in mice. The mycelia and ethanol extracts reduced the cerebral amyloid beta non compact plaques and increased the amounts of the insulin degrading enzyme as well as other benefits (decreasing amount of astrocytes and plaque activated microglia, promotion of hippocampal neurogenesis).

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133811/ -Zhang J, An S, Hu W, Teng M, Wang X, Qu Y, Liu Y, Yuan Y, Wang D. The Neuroprotective Properties of Hericium erinaceus in Glutamate-Damaged Differentiated PC12 Cells and an Alzheimer's Disease Mouse Model. Int J Mol Sci. 2016 Nov 1;17(11):1810. doi: 10.3390/ijms17111810. PMID: 27809277; PMCID: PMC5133811.

neuroprotective properties of lions mane - Study by Zhang et al. in 2016, investigating neuroprotective effects of H. erinaceus in Alzheimers mouse model. It enhanced autonomic movements

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4895996/ - Cheng JH, Tsai CL, Lien YY, Lee MS, Sheu SC. High molecular weight of polysaccharides from Hericium erinaceus against amyloid beta-induced neurotoxicity. BMC Complement Altern Med. 2016 Jun 7;16:170. doi: 10.1186/s12906-016-1154-5. PMID: 27266872; PMCID: PMC4895996.

lions mane and amyloid beta plaques in rats - Study by Cheng et al. in 2016 found that H. erinaceus had neuroprotective properties against amyloid beta neurotoxicity. Free radical scavenging rate increased with a higher concentration of HE polysaccharides (antioxidant effects). Also reduced AB induced mitochondrial membrane potentials and prevented AB induced cell shrinkage and nuclear degradation

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283924/ - Li IC, Chang HH, Lin CH, Chen WP, Lu TH, Lee LY, Chen YW, Chen YP, Chen CC, Lin DP. Prevention of Early Alzheimer's Disease by Erinacine A-Enriched Hericium erinaceus Mycelia Pilot Double-Blind Placebo-Controlled Study. Front Aging Neurosci. 2020 Jun 3;12:155. doi: 10.3389/fnagi.2020.00155. PMID: 32581767; PMCID: PMC7283924.

study with Alzheimer’s - A double blind, placebo controlled study with human participants by Li et al. in 2020 found that an intervention of 350 mg for 49 weeks improved contrast sensitivity and increased scores on the CASI (cognitive abilities screening instrument), MMSE (mini mental state examination), and IADL (instrumental activities of daily learning) in pts with mild Alzheimers disease.

#LionsManeBenefits #BrainHealthMatters #NaturalCognitiveBoost