Indianapolis Colts vs Jacksonville Jaguars Prediction and Picks - Football Best Bet for 9-10-23

If you are looking for NFL football picks and predictions for the Week 1 NFL matchup between the Indianapolis Colts and Jacksonville Jaguars, we have you covered! Our NFL football handicapping experts discuss the opening weekend from a sports betting perspective, sharing their picks and predictions vs. the current odds.

#nflpicks #nflpredictions #nflbetting

Jacksonville Jaguars at Indianapolis Colts Betting Preview

Teams: Jacksonville Jaguars (@Jaguars) at Indianapolis Colts (@Colts)

Location: Lucas Oil Stadium, Indianapolis, IN

TV: CBS
Radio: Jaguars Radio Network, Colts Radio Network
Online: NFL+

Spread: Colts -3
Total: 44.5

Interesting fact: The Jaguars and Colts are AFC South rivals and have played each other twice a year since 1995. The Colts lead the all-time series 32-21.

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