Pittsburgh Steelers vs San Francisco 49ers Prediction and Picks - Football Best Bet for 9-10-23

If you are looking for NFL football picks and predictions for the Week 1 NFL matchup between the San Francisco 49ers and Pittsburgh Steelers, we have you covered! Our NFL football handicapping experts discuss the opening weekend from a sports betting perspective, sharing their picks and predictions vs. the current odds.

#nflpicks #nflpredictions #nflbetting

San Francisco 49ers at Pittsburgh Steelers Betting Preview

Teams: San Francisco 49ers (@49ers) at Pittsburgh Steelers (@Steelers)

Location: Acrisure Stadium, Pittsburgh, PA

TV: FOX
Radio: 49ers Radio Network, Steelers Radio Network
Online: NFL+

Spread: 49ers -2.5

Total: 41

Interesting fact: The 49ers and Steelers are two of the most storied franchises in NFL history, having played each other in Super Bowl XVI and Super Bowl XLIII. The 49ers lead the all-time series 26-23.

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