Virus evolution by antibodies + BA 2 Omicron - COVID-19 vaccines update 40

2 years ago
27

How does the virus evolve inside an infected person - we commence this story with a new demonstration in a vaccinated patient, and relapse to a well-documented history in COVID-19 patients, and how antibodies can be contributing to such viral evolution. This also leads us to a hypothesis as to why evolving variants might show up in wastewater prior to taking over a population. We conclude with how the BA2 variant of the Omicron is different from the BA1 variant, demonstrating continuous uninterrupted evolution of the virus.

Described content:
Vaccine patient variants: https://www.sciencedirect.com/science/article/pii/S1201971222001230
Variants database: https://cov-lineages.org/lineage_list.html
Innunocompromised host: https://www.nejm.org/doi/10.1056/NEJMc2031364
Cancer host: https://linkinghub.elsevier.com/retrieve/pii/S0092-8674(20)31456-2
HIV host: https://www.medrxiv.org/content/10.1101/2021.06.03.21258228v1.full-text
Prolonged infection variants: https://academic.oup.com/ve/article/7/2/veab078/6377925
Evolution speed: https://www.clinicalmicrobiologyandinfection.com/article/S1198-743X(20)30440-7/fulltext
Immune escape co-evolution: https://www.science.org/doi/10.1126/science.abg0821
Convalescent plasma host: https://www.nature.com/articles/s41586-021-03291-y
GIT variant evolution: https://genomemedicine.biomedcentral.com/articles/10.1186/s13073-021-00847-5
GIT viral load: https://www.gastrojournal.org/article/S0016-5085(20)30448-0/fulltext
Viral load impact: https://academic.oup.com/ve/article/7/2/veab078/6377925
BA2 Omicron: https://arxiv.org/abs/2202.05031

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