10 months ago

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https://x.com/AsherPress/status/1666928117603082241?s=20
🔷 This is a ten-part video series summarizing the key messages of vaccinologist Dr. Geert Vanden Bossche's new book,
' The Inescapable Immune Escape Pandemic
-- Nobody Can Conceal The Science That Nature Is Now Desperate to Unveil -- Societies in Highly Vaccinated Countries Will Be Caught By Surprise.'
https://www.youtube.com/playlist?list=PLUcWTwBjAd0i2zLCZ1F2XwKoUbcuiK0Ms
https://braintrain.mykajabi.com/the-inescapable-immune-escape-pandemic

This as a Video Thread on Twitter: https://threadreaderapp.com/thread/1666928117603082241.html

1. How mRNA Vaccines and Vaccine Breakthrough Infections Drive Viral Immune Escape Dynamics

🔹 The development of herd immunity to COVID-19 has been hindered by mRNA vaccines and vaccine breakthrough infections of new Omicron variants. Instead, highly vaccinated populations are exerting herd immune pressure on viral infectiousness.

2. Only Trained Cellular Innate Immunity Yields Durable Protection During An Immune Escape Pandemic

🔷 During a pandemic of an acute self-limiting viral infection, the best way to protect ourselves is not through vaccination but through training of our innate immune system. Training our body's innate immunity is the best way to guard against potentially highly virulent SARS-CoV-2 variants. Although both cell-based innate immunity and virulence-inhibiting, non-neutralizing antibodies effectively protect against (severe) disease caused by any SARS-CoV-2 variant, only trained cell-based innate immunity has a durable sterilizing effect. This is why healthy unvaccinated individuals are now largely protected from symptomatic infection and critically contribute to herd immunity.

3. Is Covid Vaccine Protection Durable?

🔷 People who have been vaccinated against COVID-19 are still benefiting from protection against severe illness, but relying solely on weak and short-lived antibodies means that protection is suboptimal and only temporary. Re-exposure to the virus or a vaccine booster may initially sustain protection, but not without increasing immune selection pressure on viral pathogenicity.

4. Is the Covid-19 Pandemic Calming Down?

🔷 Currently, the absence of high hospitalization and mortality rates due to COVID-19 might create a false sense of security. However, ongoing evolutionary dynamics of the virus pose an imminent threat to vaccinated individuals in highly vaccinated countries.

5. The Insidiousness of Reduced Pathogenicity in Covid-19

🔷 Don't be fooled into thinking that a decrease in the pathogenicity of the virus means we have achieved herd immunity and only need to bother about an annual update, as in the case of seasonal flu vaccines. The reduced pathogenicity we are seeing is due to the protective effect of a new brand of antibodies (i.e., 'non-neutralizing' antibodies). As the latter are weak and not long-lived, they exert immune selection pressure on the very pathogenicity of the virus, which could present us with an even greater health threat in the future. 🔷 Are our antibodies still effective against new viruses? Scientists are working hard to understand how our bodies respond to new virus variants, like the Omicron XBB, to ensure we remain protected.

6. Omicron Causes Enhanced Large-Scale Immune Escape Dynamics

🔷The advent of Omicron caused viral immune escape dynamics to reach a point of no return, transforming the immune escape pandemic into an 'inescapable' self-catalyzing chain of enhanced immune escape, instead of driving it into endemicity.

7. Trained-Cell-Based Innate Immunity: How It Protects the Unvaccinated from Covid19 Escape Variants

🔷 Trained-cell-based innate immunity provides strong sterilizing immunity, so unvaccinated people are not to blame for natural immune selection and dominant propagation of continuously evolving COVID-19 immune escape variants.

8. Breakthrough Infections Via Diminished Neutralizing Capacity of Vaccine-Induced Antibodies

🔷 Mass vaccination generated an immune escape landscape where vaccine breakthrough infections enabled Omicron to resist the neutralizing capacity of antibodies, leading to an overall weakened immune response, thereby further enhancing viral immune escape.

9. Breaking the Blockade: SARS-CoV-2 Adapting to Vaccine Immunity

🔷 With more people getting vaccinated against COVID-19, it is important to know that the virus more readily adapts, selecting variants capable of breaking through suboptimal vaccine-mediated immune pressure.

10. Risks of mRNA Covid-19 Vaccines: Impact on Individual and Public Health

🔷 mRNA-based Covid-19 vaccines are considered problematic from both an individual and public health perspective due to their ability to shift the focus of the immune response to poorly immunogenic domains of spike protein.
However, individuals who have received a single dose of an mRNA-based COVID-19 vaccine or a maximum of two doses of a non-mRNA vaccine, and subsequently experience a symptomatic breakthrough infection, are believed to retain the ability to train the broadly protective capacity of their cell-based innate immune system.

http://drgeert.com
Twitter @GVDBossche
Dr. Geert Vanden Bossche
https://www.youtube.com/playlist?list=PLUcWTwBjAd0i2zLCZ1F2XwKoUbcuiK0Ms

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