Praxisklinik für Gastroenterologie und Proktologie in Leipzig, Thomas Körner

Mapping of a target region of allelic loss to a 0.5-cM interval on chromosome 22q13 in human colorectal cancer
Article
Full-text available
November 1999
Antoni CastellsYasushi InoDavid N. Louis[...]Anil K. Rustgi
Chromosomal allelic losses have a varying frequency in colorectal cancer. The aim of this study was to define the target region of allelic loss on chromosome 22q in human colorectal carcinogenesis. Fifty-seven pairs of matched normal colonic mucosa and tumor s​p​e​
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Fatal Non-01 Vibrio cholerae Septicemia in Chronic Lymphocytic Leukemia
Article
December 1982
Mark I. SiegelArvey I. Rogers
The potential of non-01 Vibrio cholerae as human pathogens is assuming greater clinical importance. They are also capable of producing a spectrum of illness that is not confined to the gastrointestinal or biliary tracts. We report a case of fatal non-01 Vibrio cholerae s​e​p​
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Interaction of enteropathogenic Escherichia coli 0111 with rabbit intestinal mucosa in vitro
Article
May 1989
H EmbayeRoger BattJon Richard Saunders[...]C.A. Hart
A model system using rabbit intestinal mucosal explants has been developed to examine the characteristic ultrastructural damage to the brush border induced by enteropathogenic Escherichia coli 0111. In this model, as in others, bacterial adherence to the m​i​c​r​o​v​i​l​l​
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Diarrhea Caused by Escherichia Coli Serotype 0127: B8; Microbiologic and Clinical Aspects
Article
August 1959
George M. EisenbergAlfred P. SpivackWilliam Weiss[...]Harrison F. Flippin
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Modulation of host response to Escherichia coll 0157:H7 infection by anti-CD18 antibody in rabbits
Article
July 1994
Elizabeth J ElliottZhe LiCameron Bell[...]Edward O'Loughlin
Escherichia coli O157:H7 infection induces diarrhea, severe colitis, and colonic electrolyte transport abnormalities characterized by decreased Na absorption and Cl secretion. The aim of this study was to examine the role of the host inflammatory response in inducing d​i​s​
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Studies in gnotobiotic piglets on Non-0157:H7 Escherichia coli serotypes isolated from patients with hemorrhagic colitis
Article
April 1988
Saul TziporiKaye I. WachsmuthJane SmithersCraig Jackson
A number of verotoxin-producing Escherichia coli strains isolated from sporadic cases of hemorrhagic colitis in the United States over the last 5 yr were shown to belong to serogroups other than O157:H7-the serotype originally implicated in this disease. Experimental i​
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MLN-02 in IBD: is "super-selective" really super?
Article
June 2006
Russell Cohen
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Clostridium difficile Infection Caused by the Epidemic BI/NAP1/027 Strain
Literature Review
June 2009
Jennifer R O'ConnorStuart JohnsonDale N Gerding
Rates and severity of Clostridium difficile infection (CDI) in hospitals in North America and Europe have increased since 2000 and correlate with dissemination of an epidemic strain characterized by higher than usual toxin A and B production, the presence of a third toxin, binary t​o​
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Association of gastric adenocarcinoma with the HLA class II gene DQB1*0301
Article
September 1996
J E LeeAndrew LowyWA Thompson[...]J D Reveille
The HLA class II gene DQB1*0301 has been linked to several cancers. This study was designed to determine if HLA-DQB1*0301 is present at altered frequency in patients with gastric, colorectal, or pancreatic adenocarcinoma. Oligotyping for HLA-DQB1*0301 was performed for 1​5​
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Human risk allele HLA-DRB1*0405 predisposes class II transgenic Ab0 NOD mice to autoimmune pancreatitis
Article
March 2010
Tobias L FreitagCandace M ChamHsiang-Hsuan Sung[...]Grete Sønderstrup
Autoimmune pancreatitis (AIP) underlies 5%-11% of cases of chronic pancreatitis. An association between AIP and the human leukocyte antigen (HLA)-DRB1*0405/DQB1*0401 haplotype has been reported, but linkage disequilibrium has precluded the identification of predisposing
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Effects of OKY 046, a thromboxane-synthase inhibitor, on renal function in nonazotemic cirrhotic patients with ascites
Article
July 1988
Paolo GentiliniGiacomo LaffiElisabetta Meacci[...]Gianpiero Buzzelli
To assess the possible role of increased renal thromboxane A2 (TXA2) synthesis in nonazotemic patients with cirrhosis and ascites and to establish the potential beneficial effect of inhibitors of renal TXA2 production in this clinical setting, we administered OKY 046, a selective T​
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The HLA alleles DRB1*13 and DQB1*06 are associated to Whipple's disease
Article
June 2009
Miryam MartinettiFederico BiagiCa Badulli[...]Gino R Corazza
Whipple's disease is a systemic, chronic, relapsing disorder caused by a combination of environmental (Tropheryma whipplei) and unknown host factors. Because it is a rare disease, the association between HLA type and Whipple's disease has been studied in only s​m​a​l​l​
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Correlation of symptoms, age, sex, and habitus with cholecystographic findings in 1,000 consecutive examinations
Article
June 1957
C L HINKELG A MOLLER
Most of the patients in this study were referred for cholecystography with complaints of excessive belching, gas pains, and selective dyspepsia. There was no correlation between these symptoms and the cholecystographic findings. Excessive gas, vague upper abdominal pain, h​i​s​t​
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Cirrhosis After Repeated Trichloroethylene and 1,1,1-Trichloroethane Exposure
Article
November 1982
Dwain L. ThieleEdwin H. EigenbrodtAthol J. Ware
Acute hepatotoxicity has been described in patients exposed to either trichloroethylene or 1,1,1-trichloroethane, but there have been previous reports of chronic liver disease induced by these agents. We describe a patient who developed cirrhosis and portal hypertension a​f​t​e​r​
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Cellular proliferation in proximal and distal rat colon during 1,2-Dimethylhydrazine-induced carcinogenesis
Article
September 1988
Thomas McGarrityLaurence PeifferPamela Colony
Sequential changes in proliferative parameters in proximal and distal colonic crypts were studied during 1,2-dimethylhydrazine-induced carcinogenesis using [3H]thymidine autoradiography as a probe. 1,2-dimethylhydrazine (20 mg/kg) and vehicle (ethylenediaminetetraacetic a​c​i​
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Comparison of resistant starch with cellulose diet on 1,2-dimethylhydrazine-induced colonic carcinogenesis in rats
Article
January 1996
J SakamotoS NakajiK Sugawara[...]A Munakata
Epidemiological and experimental studies have shown that dietary fiber may prevent colon cancer. Resistant starch, like dietary fiber, is not subject to digestion in the small intestine. However, it is unknown whether resistant starch inhibits colonic carcinogenesis. In vitro studies h​a​
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Enhancement of 1,2-dimethylhydrazine-induced rectal carcinogenesis following chronic ethanol consumption in the rat
Article
June 1984
H K SeitzP CzyganR Waldherr[...]B Kommerell
The incidence, distribution, size, and histopathology of grossly visible intestinal tumors induced by the parenteral administration of 1,2-dimethylhydrazine dihydrochloride were examined in 32 paired rats fed a nutritionally adequate liquid diet containing 36% of total calories either as
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Effects of small bowel transection, resection, or bypass in 1,2-dimethylhydrazine-induced rat intestinal neoplasia
Article
May 1983
Charles H. ScudamoreHugh J. Freeman
The incidence, distribution, size, and histopathology of rat small and large bowel tumors induced by sequential administration of 1,2-dimethylhydrazine followed by either small bowel resection, 50% jejunoileal resection, or 50% jejunoileal bypass were examined in addition to m​e​
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The PREM(1,2,6) model predicts risk of MLH1, MSH2, and MSH6 germline mutations based on cancer history
Article
January 2011
Fay KastrinosEwout W SteyerbergRowena Mercado[...]Sapna Syngal
We developed and validated a model to estimate the risks of mutations in the mismatch repair (MMR) genes MLH1, MSH2, and MSH6 based on personal and family history of cancer. Data were analyzed from 4539 probands tested for mutations in MLH1, MSH2, and MSH6. A m​
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Adaptive Response of Humans to Changes in Dietary Calcium: Relationship Between Vitamin D Regulated Intestinal Function and Serum 1,25-Dihydroxyvitamin D Levels
Article
March 1983
Daniel BikleRobert H. HermanSam Hull[...]Bernard Halloran
We developed intestinal biopsy procedures in chicks that were extended to humans to study the role of vitamin D in regulating intestinal adaptation to dietary calcium. By comparing biopsy specimens from rachitic chicks (D-) to those from vitamin D-supplemented chicks (​D​
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Inhibitory effect of 22-Oxa-1,25-dihydroxyvitamin D3 on the proliferation of pancreatic cancer cell lines
Article
May 1996
Shigeyuki KawaK YoshizawaM Tokoo[...]Kenichi Furihata
Effective chemotherapy for pancreatic cancer is urgently needed. The aim of this study was to compare the anti-proliferative activity of a new vitamin D3 analogue, 22-oxa-1,25-dihydroxyvitamin D3 (22-oxa-calcitriol), on pancreatic cancer cells lines with that of 1,25-d​i​h​y​d​r​o​x​y​v​i​t​a​
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Hypercalcemia due to endogenous overproduction of 1,25-dihydroxyvitamin D in Crohn's disease
Article
June 1998
Xavier Bosch
Hypercalcemia may occur in various granulomatous diseases. Two patients with Crohn's disease who had hypercalcemia, hypercalciuria, and excessively high serum levels of 1,25-dihydroxyvitamin D [1,25(OH)2D] are described. Both had numerous noncaseating, e​
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Altered Oligosaccharide Structures Reduce Colitis Induction in Mice Defective in beta-1,4-Galactosyltransferase
Article
February 2012
Shinichiro ShinzakiHideki IijimaHironobu Fujii[...]Eiji Miyoshi
Oligosaccharide modifications induce various functional changes in immune cells. The galactose-deficient fraction of fucosylated IgG oligosaccharides is increased, whereas that of β-1,4-galactosyltransferase I (B4GalTI) is reduced, in patients with Crohn's disease. We i​n​v​
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Experimental Production of Mallory Bodies in Mice by Diet Containing 3,5-Diethoxycarbonyl-1,4-Dihydrocollidine
Article
July 1982
Hidejiro YokooThomas R. HarwoodDarlene RackerSaima Arak
The first experimental production of Mallory bodies was reported by Denk et al. in 1975 in mice fed griseofulvin. We discovered a second chemical capable of producing Mallory bodies in the mouse liver in a manner similar to griseofulvin. Male Swiss albino mice were fed a p​
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Loss of Inositol 1,4,5-Trisphosphate Receptors From Bile Duct Epithelia Is a Common Event in Cholestasis
Article
November 2003
Kazunori ShibaoKeiji HirataMarie E RobertMichael H Nathanson
Cholestasis is one of the principal manifestations of liver disease and often results from disorders involving bile duct epithelia rather than hepatocytes. A range of disorders affects biliary epithelia, and no unifying pathophysiologic event in these cells has been identified as the c​a​u​s​
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Secretagogues cause ubiquitination and down-regulation of inositol 1,4,5-trisphosphate receptors in rat pancreatic acinar cells
Article
June 1999
Richard J.H. WojcikiewiczStephen A. ErnstDavid Yule
The action of several exocrine pancreas secretagogues depends on the second messenger inositol 1,4, 5-trisphosphate (IP3), which, via endoplasmic reticulum-located IP3 receptors, mobilizes intracellular Ca2+ stores. Signaling pathways like this one are regulated a​t​
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The Type II inositol 1,4,5-trisphosphate receptor can trigger Ca2+ waves in rat hepatocytes
Article
April 2002
Keiji HirataThomas PuslAllison F O'Neill[...]Michael H Nathanson
Ca2+ regulates cell functions through signaling patterns such as Ca2+ oscillations and Ca2+ waves. The type I inositol 1,4,5-trisphosphate receptor is thought to support Ca2+ oscillations, whereas the type III inositol 1,4,5-trisphosphate receptor is thought to initiate Ca2+
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Beneficial effect of fructose-1,6-bisphosphate on mitochondrial function during ischemia-reperfusion of rat liver
Article
July 1995
Wakaba SanoFusao WatanabeHiroshi Tamai[...]Makoto Mino
Several groups have reported that administration of fructose-1,6-bisphosphate (FBP) reduces ischemic injury. The aim of this study was to determine the protective effect of FBP on the impairment of mitochondrial oxidative phosphorylation by ischemia-reperfusion i​n​j​u​
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The Zinc Finger Protein ZBTB20 Regulates Transcription of Fructose-1,6-Bisphosphatase 1 and β Cell Function in Mice
Article
February 2012
Ye ZhangAlice XieLuting Zhou[...]Weiping Zhang
Fructose-1,6-bisphosphatase (FBP)-1 is a gluconeogenic enzyme that regulates glucose metabolism and insulin secretion in β cells, but little is known about how its transcription is controlled. The zinc finger protein ZBTB20 regulates glucose homeostasis, so we i​n​v​
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Proteolytic enzyme activity. I. Urinary proteolytic activity at pH 1.5 in adults
Article
November 1957
H L SEGALL L MILLERF REICHSMAN[...]G L GLASER
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Proteolytic enzyme activity. II. Gastric and urinary proteolytic activities at pH 1.5 and 3.5
Article
November 1957
L L MILLERH L SEGALE J PLUMB
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Pledges of $1.9 Billion at Avian Influenza Conference
Article
April 2006
Les Lang
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Support for ideas: the last 1000 years and the next ten. The Presidential Address
Article
October 1983
J T Farrar
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Transvenous liver biopspy. An experience based on 1000 hepatic tissue samplings with this procedure
Article
September 1982
D LebrecG GoldfarbC Degott[...]J P Benhamou
Transvenous liver biopsy was attempted 1033 times in 932 patients in whom percutaneous liver biopsy was contraindicated. A hepatic tissue specimen was obtained in 1000 out of these 1033 attempts. The specimen was unfragmented and/or large enough to allow correct e​v​
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Pathologic observations of intrahepatic peribiliary glands in 1000 consecutive autopsy livers: Heterotopic pancreas in the liver
Article
June 1990
Tadashi TeradaYasuni NakanumaAkira Kakita
One thousand consecutively autopsied livers were examined for intrahepatic heterotopic pancreas. Heterotopic pancreas in the liver was found in 41 (4.1%) of the 1000 livers. It occurred with nearly equal frequency in "normal" livers and variously diseased livers. H​i​s​t​o​l​o​g​i​
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Multicenter trial of d-α-tocopheryl polyethylene glycol 1000 succinate for treatment of vitamin E deficiency in children with chronic cholestasis
Article
July 1993
Ronald J SokolNancy ButlerColin Conner[...]Joseph Levy
Malabsorption and deficiency of vitamin E causing neurological degeneration are common consequences of chronic childhood cholestatic liver disease. The objective of this study was to determine the long-term efficacy and safety of d-alpha-tocopheryl polyethylene g​l​y​c​
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Liver biopsy: Complications in 1000 inpatients and outpatients
Article
February 1978
Perrault JPDouglas B. McGillBeverly J. OttWilliam F. Taylor
We prospectively evaluated risk factors in 1000 consecutive patients who underwent liver biopsy: 829 outpatients and 171 inpatients. The two groups were similar except that the outpatient group had a higher percentage of patients with hepatitis-cirrhosis and a lower percentage
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Treatment of vitamin E deficiency during chronic childhood cholestasis with oral d-α-tocopheryl polyethylene glycol-1000 succinate
Article
December 1987
Ronald J SokolJames E HeubiNancy Butler[...]Arnold Silverman
Treatment of vitamin E deficiency during chronic childhood cholestasis is hampered by the poor intestinal absorption of available oral preparations of vitamin E when bile flow is severely impaired; thus parenteral vitamin E has been the only effective therapy for many c​h​i​l​
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Three Sequencing Companies Join the 1000 Genomes Project
Article
August 2008
Les Lang
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Phillips, S. F.: Conservation of sodium, chloride, and water by the human colon. Gastroenterology56, 101-108
Article
February 1969
Ghislain DevroedeSidney F. Phillips
The transport of electrolytes by the human colon has been studied by perfusing the entire colon with isotonic solutions containing different concentrations of sodium, chloride, potassium, and bicarbonate. Absorption of sodium and chloride against large concentration g​r​a​d​i​e​n​
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Bile-ology 101
Article
August 2001
Richard H. Moseley
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Hamelin R, Flejou J-F, Muzeau F, Potet F, Larent Puig P, Fekete F, Thomas GTP53 gene mutations and p53 protein immunoreactivity in malignant and premalignant Barrett's esophagus. Gastroenterology 107: 1012-1018
Article
November 1994
R HamelinJ F FléjouF Muzeau[...]G Thomas
Limited data are available regarding TP53 gene alterations in Barrett's esophagus. This study was undertaken to characterize TP53 mutations and p53 protein immunoreactivity in cancers and preinvasive lesions of Barrett's esophageal mucosa. Seventeen Barrett's a​d​e​n​o​c​a​r​c​i​
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32 Reads146 Citations
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Unrestricted diet in the treatment of duodenal ulcer. Gastroenterology, 56 (6), 1016-1026
Article
July 1969
E BuchmanD T KaungK DolanR N Knapp
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Pisegna JR, Norton JA, Slimak GG, Metz DC, Maton PN, Jensen RT. Effects of curative resection on gastric secretory function and antisecretory drug requirement in the Zollinger-Ellison syndrome. Gastroenterology. 102: 767-778
Article
April 1992
Joseph R PisegnaJeffrey A NortonG G Slimak[...]R T Jensen
The chronic hypergastrinemia in diseases such as the Zollinger-Ellison syndrome has trophic effects on the gastric mucosa, causing increased parietal cell mass reflected by increased maximal acid output (MAO) and basal acid output (BAO). The time course for the d​e​
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