11 months ago

A new study out of Northwestern University has shown that as we age the length of our genes changes and drive the aging process, but can this process now be altered with therapeutics?
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Links:
https://www.nature.com/articles/s43587-022-00317-6
https://pubmed.ncbi.nlm.nih.gov/37118543/
https://www.nia.nih.gov/news/aging-linked-rna-length-imbalance
https://bit.ly/3p276Jo
https://bit.ly/42e6gYr

Northwestern University researchers have discovered a previously unknown mechanism that drives the aging process. In this new study the researchers used artificial intelligence to analyze data from a wide variety of tissues, collected from humans, mice, rats and killifish.
They discovered that the length of genes can explain most molecular-level changes that occur during the aging process. All cells must balance the activity of both long and short genes. The researchers found that longer genes are linked to longer lifespans, and shorter genes are linked to shorter lifespans. They also found that aging genes change their activity according to their length. More specifically, aging is accompanied by a shift in activity towards short genes; this shift causes gene activity in the cells to become unbalanced. This shift in gene activity and the subsequent unbalance was found to be near universal. The researchers uncovered this pattern across several animals, including humans, and across many different tissues types, including blood, muscle, bone - and organs including the liver, heart, intestines, the brain and the lungs. This new finding could potentially could lead to interventions designed to slow the pace of, or even reverse aging.
Thomas Stoeger PhD, who led the study from the Department of Chemical and Biological Engineering at Northwestern University, said "The changes in the activity of genes are very, very small, and these small changes involve thousands of genes. We found this change was consistent across different tissues and in different animals. We found it almost everywhere.
I find it very elegant that a single, relatively concise principle seems to account for nearly all of the changes in activity of genes that happen in animals as they age."
Luís A.N. Amaral, Professor of Chemical and Biological Engineering at Northwestern University, and senior author of the study said "The imbalance of genes causes aging because cells and organisms work to remain balanced, what physicians denote as homeostasis. Imagine a waiter carrying a big tray. That tray needs to have everything balanced. If the tray is not balanced, then the waiter needs to put in extra effort to fight the imbalance. If the balance in the activity of short and long genes shifts in an organism, the same thing happens. It's like aging is this subtle imbalance, away from equilibrium. Small changes in genes do not seem like a big deal, but these subtle changes are bearing down on you, requiring more effort."
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