Advocacy for Mushroom vape Tiger Milk Mushroom

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8175741/

A clinical study on the effects of tiger milk mushroom on 50 subjects…

It is my hopes to get together a facility, a lounge/spa, with a pulmonologist to help with an observational study, of those of whom buy in to participate, and monthly we record their pulmonary improvements…

Discussion
This study is the first to report the beneficial effects of TMM on respiratory health through clinical approach. Our findings revealed that TMM supplementation is effective in improving overall respiratory health and immunity of the participants. Few parameters being assessed as the indicator of respiratory health has shown a significant improvement by the end of this study. Those parameters included pulmonary function, respiratory symptoms, VAS, interleukin level and immunoglobulin level. Ratio of FEV1 to FVC that reflects pulmonary function has shown 27.2% improvement after three months of TMM supplementation..

... Apart from inhibitory action against TNF-α production, TMM also exhibited regulatory effect against macrophages4. The regulatory effect of TMM was suggested to be attributed by its high linoleic acid content. Linoleic acid inhibits inflammatory responses from macrophage through inactivation of nuclear factor (NF)-kappaB and activator protein-1 (AP-1) by suppressing oxidative stress and signal transduction pathway of signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK)-136.

…The suppressing effect of TMM on overproduction of IL-1β and IL-8 is crucially important to conserve the lungs’ function and to prevent any damage from pro-inflammatory cytokines40. The improved pulmonary function, NSQ and VAS scoring from our findings have further validated that. Recent study suggested that any treatment targeting cytokine could potentially be an evolving treatment strategy in chronic inflammatory airway diseases15.

…NSQ is a simple and accurate scoring system developed specifically to evaluate the symptoms caused by sinonasal diseases, such as sneezing, nasal obstruction, nasal discharge, olfactory loss, cough and quality of life… Sinonasal disease was mainly triggered by persistent or recurrent episodes of infection or inflammation of one or both sinus cavities43...

…TMM supplementation is important to prevent colonization of respiratory tract by pathogens and penetration of antigens through epithelial cells. The antiviral properties of IgA were well established by studies on Sendai virus, influenza virus, and rotavirus51. Most recent studies also suggested the potential role of IgA in fighting SARS-CoV-2 infection12,13..

…Recent review pointed out that although definitive data is still lacking, but available evidences suggested that dietary intake of antioxidant is closely associated with better pulmonary function, less lung function decline and reduced risk of COPD56. Our result indicated that three months of TMM supplementation can effectively increase total antioxidant capacity by almost 70%…

…TMM supplementation could potentially exert a protective effect against inflammation-related respiratory diseases as polyphenols had been proven to effectively reduce inflammation, by (1) up-regulating antioxidant gene expression, (2) attenuating endoplasmic reticulum stress signalling, (3) blocking pro-inflammatory cytokines, (4) suppressing inflammatory gene expression by stimulating histone deacetylase activity, or (5) activating transcription factors that antagonize chronic inflammation61…

…Similarly, oral administration of TMM in diabetic animal model also found that elevated glutathione (GSH) level, superoxide dismutase (SOD), and catalase (CAT) activities to be associated with reduced lipid peroxidation66. Reduced lipid peroxidation is important to prevent many detrimental effects on airway function which were caused by oxidative stress, including airway hyperresponsiveness67, mucus hypersecretion68, epithelial shedding69, airway smooth muscle contraction70, vascular exudation71, and increased vascular permeability72.

Conclusion:
Although TMM is well-known for its ethnomedicinal uses in curing many ailments and to improve respiratory health, but scientific evidences that supporting its therapeutic uses were limited to in vivo and in vitro models. Present work is the first to study the efficacy of TMM supplementation to improve respiratory health through a clinical approach. Findings revealed that TMM supplementation can effectively improve the respiratory health, immunity, as well as overall antioxidant status. Thus, suggesting TMM supplementation as a potential adjuvant therapy to the current drugs used for the management of respiratory diseases. Nonetheless, the lack of a placebo group is one important limitation in this study. Randomized controlled trial is recommended for future study to validate our findings. In addition, this study was not registered with any Clinical Trial Registry and will consider registering future studies.

A class act…