2 years ago

265

Portland Oregon
Peoples Republic of Multnomah County

https://www.cnn.com/2023/03/28/us/covenant-school-shooting-nashville-tennessee-tuesday/index.html?cid=external-feeds_iluminar_msn

https://www.webmd.com/mental-health/signs-sociopath

https://www.mayoclinic.org/diseases-conditions/narcissistic-personality-disorder/symptoms-causes/syc-20366662

Psychedelic Therapeutics
https://www.science.org/doi/10.1126/science.adf0435
""Abstract
Decreased dendritic spine density in the cortex is a hallmark of several neuropsychiatric diseases, and the ability to promote cortical neuron growth has been hypothesized to underlie the rapid and sustained therapeutic effects of psychedelics. Activation of 5-hydroxytryptamine (serotonin) 2A receptors (5-HT2ARs) is essential for psychedelic-induced cortical plasticity, but it is currently unclear why some 5-HT2AR agonists promote neuroplasticity, whereas others do not. We used molecular and genetic tools to demonstrate that intracellular 5-HT2ARs mediate the plasticity-promoting properties of psychedelics; these results explain why serotonin does not engage similar plasticity mechanisms. This work emphasizes the role of location bias in 5-HT2AR signaling, identifies intracellular 5-HT2ARs as a therapeutic target, and raises the intriguing possibility that serotonin might not be the endogenous ligand for intracellular 5-HT2ARs in the cortex.""

https://www.sciencedirect.com/topics/neuroscience/psilocybin

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3079328/
""Type-specific dendrite morphology is a hallmark of the neuron and has important functional implications in determining what signals a neuron receives and how these signals are integrated. During the past two decades, studies on dendritic arborization neurons in Drosophila melanogaster have started to identify mechanisms of dendrite morphogenesis that may have broad applicability to vertebrate species. Transcription factors, receptor–ligand interactions, various signalling pathways, local translational machinery, cytoskeletal elements, Golgi outposts and endosomes have been identified as contributors to the organization of dendrites of individual neurons and the placement of these dendrites in the neuronal circuitry. Further insight into these mechanisms will improve our understanding of how the nervous system functions and might help to identify the underlying causes of some neurological and neurodevelopmental disorders.""

https://www.sciencedirect.com/topics/neuroscience/psilocybin
Psilocybin
Psilocybin was isolated in 1957 from the Psilocybe mexicana mushroom and it has since been identified as a component of over 75 distinct mushroom species.255 Psilocybin-containing mushrooms, also called ‘magic mushrooms’, are used recreationally.256 Psilocybin and psilocin are listed as Schedule I drugs under the United Nations 1971 Convention on Psychotropic Substances.

Psilocybin content varies based on such factors as species and preparation. The most commonly used mushroom is Psilocybe cubensis, which contains 10–12 mg of psilocybin per gram of dried mushrooms; effective oral doses range from 6 to 20 mg and about 40 µg/kg is considered the threshold level for intoxication.257

Psilocin is a high-affinity agonist at serotonin 5-HT2A receptors, which are especially prominent in the prefrontal cortex. It increases cortical activity secondary to down-stream postsynaptic glutamate effects. It is also active at 5-HT1A, 5-HT1D, and 5-HT2C receptors, although these are thought to play a lesser role in its effects. In the presence of the 5-HT2A antagonist ketanserin, the changes in mental state that psilocybin typically causes do not occur.258

Loading 1 comment...