New Research: Not ALL Senescent Cells are Bad!

As we age the number of senolytic cells or zombie cells we have in our body increases, this is a bad thing, although a new study seems to show that some zombie cells actually help in the healing process.Show more

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https://www.science.org/doi/10.1126/science.abf3326

"Zombie cells" that contribute to age-related diseases also help heal damaged tissues, so wiping them out could come with major downsides. The zombie cells, scientifically known as "senescent" cells, are cells that stop multiplying due to damage or stress but don't die; this according to the National Institute on Aging. These zombie cells then release a slew of molecules that summon immune cells and this in turn spark inflammation.
The immune system regularly clears these zombies from the body, but with age, the system becomes less efficient; and as a result, the dysfunctional cells accumulate. This accumulation produces more inflammation, which in turn contributes to the development of age-related diseases such as cancer, Alzheimer's disease and osteoarthritis.
But zombie cells aren't entirely bad. This new study, conducted in lab mice and on human cells, suggested that senescent cells helped repair lung tissue after damage by encouraging stem cells to grow. Killing these zombie cells with Dasatinib, a cancer treatment, and Quercetin, a naturally occurring polyphenol – a drug duo that's been studied as a potential treatment to combat aging and age-related diseases - was found to somewhat disrupted this repair.  
Tien Peng MD, an associate professor of pulmonary, critical care, allergy and sleep medicine at the University of California, San Francisco said
"We are not the first lab to implicate senescence as a wound-healing process. A 2014 study in the journal Developmental Cell found that zombie cells helped mend wounds in the skin and that their repair can also be disrupted by senolytics. This suggests that using senolytics could come at a cost, so the drugs will have to be designed to block zombie cells' bad effects without disrupting their good ones.”
To find senescent cells in the lung, researchers genetically modified mice to carry a glowing protein on the gene that codes for the protein "P16," which is overactive in many senescent cells. Whenever a cell switched on the gene, it would also churn out fluorescent proteins and start to glow. The researchers used this technique to "really amplify this signal," Professor Peng said, and thus revealed cells that carry low levels of p16; cells that may have otherwise escaped notice. Glowing cells appeared in mice's lungs shortly after birth, and their numbers increased over the rodents' life spans. The cells included fibro-blasts, which make connective tissue, as well as immune cells; they reside within a sheet-like tissue called the "basement membrane." The basement membrane is a sort of gatekeeper, it singles out and blocks harmful chemicals and pathogens from entering the lungs. But, at the same time it also allows oxygen to pass unhindered into the bloodstream.
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