6 Benefits of N-acetylcysteine (NAC) Supplementation for Longevity

1 year ago
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In this video we will look at NAC as a supplement, what benefits taking it could yield and also the possible side-effects and the daily dosages.

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Links:
https://pubmed.ncbi.nlm.nih.gov/24080471/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3036554/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5241507/
https://pubmed.ncbi.nlm.nih.gov/10968500/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343415/
https://pubmed.ncbi.nlm.nih.gov/19722195/
https://pubmed.ncbi.nlm.nih.gov/19280424/
https://bit.ly/3SbLF3h
https://bit.ly/3IcsMsl
https://www.lifeextension.com/magazine/2010/5/n-acetyl-cysteine
http://clevelandclinic.org/reproductiveresearchcenter/docs/agradoc162A.pdf
https://www.mskcc.org/cancer-care/integrative-medicine/herbs/n-acetylcysteine
https://www.fda.gov/food/cfsan-constituent-updates/fda-releases-final-guidance-enforcement-discretion-certain-nac-products

Research suggests that N-acetyl cysteine (NAC) - the supplement form of the semi-essential amino acid L-cysteine - is an effective, safe and low-cost treatment option for a range of conditions, including those that are both acute and chronic. Not only has been it been used for three decades as an effective mucolytic agent (mucous-thinner), but it also has uses including reducing inflammation, protecting the liver, and preventing/treating drug toxicity, insulin resistance and infertility due to PCOS to name a few. N-acetyl cysteine (NAC), the supplement form of cysteine, is an amino acid that helps the body create and use protective antioxidants. While cysteine is found in many high-protein foods, NAC is only acquired by taking supplements or prescription drugs. Because the human body can create some NAC from some other amino acids, so it is considered to be a “semi-essential amino acid.” That means there isn’t a daily requirement of NAC that you must get from your diet, but getting higher amounts can benefit some people. NAC is involved in the regulation of the glutamatergic system. In other words, as a precursor of L-cysteine, which results in glutathione biosynthesis, NAC (along with glutamine and glycine) is an amino acid that is needed to produce what’s arguably the most important antioxidant in the human body. The most important NAC mechanisms of action are its antioxidant and its anti-inflammatory effects. These are due to its ability to increase glutathione levels, scavenge free radicals and reduce oxidative stress. This is why it’s recommended as a potential treatment for different disorders resulting from free oxygen radicals, such as liver disease, Alzheimer’s, Parkinson’s and some cancers. Studies have shown no maternal or fetal harmful effects of NAC treatment. Certain studies have even found that NAC used in combination with vitamin E, or vitamins A and E, and essential fatty acids can reduce reactive oxygen species (ROS) and lead to pregnancy rate improvements in those struggling to become and stay pregnant, especially women with PCOS. This is because it increases levels of the antioxidant glutathione, which positively acts on insulin secretion and reduces insulin resistance, which is believed to be associated with PCOS.
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