2 years ago

A study out of New Zealand seems to show that 6 minutes of a particular type of exercise boosts a protein in the brain that works to fend of the diseases of aging.
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Links:
https://pubmed.ncbi.nlm.nih.gov/36631068/#:~:text=Fasting%20for%2020%20h%20caused,in%20peripheral%20circulation%20at%20rest.
https://physoc.onlinelibrary.wiley.com/doi/10.1113/JP283582
https://www.medicalnewstoday.com/articles/6-minutes-of-hiit-may-help-delay-onset-of-alzheimers-parkinsons
https://www.upi.com/Health_News/2023/01/12/new-zealand-study-high-intensity-exercise-brain-health/4641673500756/
https://www.sciencedaily.com/releases/2023/01/230112090919.htm

Six minutes of high-intensity exercise could extend the lifespan of a healthy brain and delay the onset of neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. This new research published in The Journal of Physiology showed that a short but intense bout of cycling increases the production of a specialized protein that is essential for brain formation, learning and memory, and could protect the brain from age-related cognitive decline. This insight on exercise is part of the drive to develop accessible, equitable and affordable non-pharmacological approaches that anyone can adopt to promote healthy aging. The specialized protein named brain-derived neurotrophic factor (BDNF) promotes neuroplasticity and the survival of neurons. Neuroplasticity is the mechanism by which the brain forms new connections and pathways. Animal studies have shown that increasing the availability of BDNF encourages the formation and storage of memories, enhances learning and overall boosts cognitive performance. These key roles and its apparent neuro-protective qualities have led to more interest into BDNF for aging research.
Travis Gibbons, a PhD candidate at the University of Otago and Lead Author of the study said "BDNF has shown great promise in animal models, but pharmaceutical interventions have thus far failed to safely harness the protective power of BDNF in humans. We saw the need to explore non-pharmacological approaches that can preserve the brain's capacity which humans can use to naturally increase BDNF to help with healthy aging."
To tease apart the influence of fasting and exercise on BDNF production, the researchers, from the University of Otago, New Zealand, compared the following factors to study the isolated and interactive effects:

• First was fasting for 20 hours
• Second, light exercise (90-minutes of low intensity cycling)
• Third, was high-intensity exercise (six-minute bouts of vigorous cycling)
• And fourth was a combination of fasting and exercise

They found that brief but vigorous exercise was the most efficient way to increase BDNF compared to one day of fasting, and that was with or without a lengthy session of light exercise.
High intensity exercise increased BDNF by four to five-fold (396 pg L-1 to 1170 pg L-1); an increase of 774 points
Fasting showed no change in BDNF concentration
Low intensity, prolonged activity showed a slight increase in BDNF concentration, (336 pg L-1 to 390 pg L-1); and increase of only 54 points.
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