Psychedelics - MDMA as a medicine

As a neuroscientist:
Long-term high dose of psilocybin can lead to changes in brain structure and function, specifically affecting neural plasticity, synaptic connectivity and the regulation of neurotransmitter systems involved in cognition and emotional processing. However, there is limited research on the long-term effects of high dose psilocybin use and more studies are needed to fully understand its impact on the brain.
As a shaman:
From a shamanic perspective, psilocybin has been used for centuries in spiritual and medicinal practices to promote insight, self-awareness and connection with the spiritual realm. Long-term high dose use of psilocybin can lead to altered states of consciousness and changes in perception that can impact behavior and worldview, potentially leading to spiritual evolution.
As an ethnobotanist:
From an ethnobotanical perspective, psilocybin has been used by indigenous cultures for centuries for spiritual and medicinal purposes, often as a sacrament in sacred ceremonies. The long-term effects of high dose psilocybin use in these cultures have not been well studied, but it is believed to play a role in shaping cultural norms, beliefs and practices. Further research is needed to understand its impact on cultural evolution