Premium Only Content

019 | Are Lipid Nanoparticles in mRNA tech - the hidden danger? | Christie Grace
Christie Grace is a consultant in biotechnology specifically on recombinant antibodies, CRISPR, mRNA, gene synthesis & Quality control. On this episode we discuss Lipid Nanoparticles (LNP) - and how they relate to mRNA technology as the delivery mechanism. We dive into the known adverse outcomes related to the LNP's with regards to clotting, damage to endothelial cells, fertility and more as well as how this was known to the CDC and NIH for years prior. The freeze-thaw process is also out to be questioned due to known ways this degrades the LNP's.
0:45 Intro
04:30 What is it about the mRNA tech that's so different? What about in the lab?
10:30 Why is the timeline questionable for the trials?
12:00 What is mRNA, how is it produced?
23:45 What & Why are LNP's important (lipid nano particles)
41:00 mRNA fragmentation within batches/vials
47:15 Could fragmentation be an accident
53:00 Freeze thaw
54:30 Ribosomal overload
1:00:00 Real life freezee thaw issues (data at the 53 min mark)
1:09:00 Does the initial trial pass the sniff test?
1:18:30 What does this mean for the public?
1:29:00 Where does this all end?
1:46:50 Top tips to stay aware
1:54:40 Where to find Christie
Follow Christie
https://twitter.com/_HeartofGrace_
Substack
https://christielauragrace.substack.com/p/lnp-liquid-nano-phantasmagoria
Follow me
Twitter - Https://twitter.com/sunnypodcasts
Insta - https://instagram.com/sunnys91
What are Ionizable Lipids (for use in Lipic Nano Particles)
https://broadpharm.com/blog/what-are-ionizable-lipids#:~:text=Ionizable%20lipids%20are%20a%20class,be%20protonated%20at%20low%20pH
Degredation of LNP
https://www.cell.com/biophysj/fulltext/S0006-3495(21)00241-1?s=03
Safety data sheets
https://cdn.caymanchem.com/cdn/msds/15100m.pdf
https://avantilipids.com/assets/products/attachments/850365C_E_7950_US.pdf
LNP Oxidative stress & toxicity (clots, cancer inducing etc.)
https://stacks.cdc.gov/view/cdc/21130
LNP Reproduction
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294055/
Misfolded proteins
https://faseb.onlinelibrary.wiley.com/doi/abs/10.1096/fj.11-186197
Aussie TGA specific batches and allocations
https://www.tga.gov.au/batch-release-assessment-covid-19-vaccines
Japan foreign substances
https://asia.nikkei.com/Spotlight/Coronavirus/COVID-vaccines/1.6m-Moderna-doses-withdrawn-in-Japan-over-contamination
Freeze thaw
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2794342/
https://threadreaderapp.com/thread/1603149749942624263.html
Spike found in brain & heart tissue
https://www.mdpi.com/2076-393X/10/10/1651
"Dansen met Janssen" (You'll have to translate the page)
https://www.metronieuws.nl/in-het-nieuws/binnenland/2021/09/kapotte-koeling-janssen-vaccins-dansen-met-janssen/
What's spike
https://www.uniprot.org/uniprotkb/P0DTC2/entry
Safety of LNP mRNA rat/monkey
https://pubmed.ncbi.nlm.nih.gov/29191134/
Circulating spike protein
https://www.ahajournals.org/doi/epdf/10.1161/CIRCULATIONAHA.122.061025
Coagulation triggered by positively charged surfaces
https://www.duo.uio.no/bitstream/handle/10852/61833/Sperling%2Bet%2Bal.pdf?sequence=1&isAllowed=y
Phosphatidylethanolamine & coagulation with VLDL
https://www.ahajournals.org/doi/full/10.1161/atvb.21.10.1695
Mouse models and human lipoprotein suitability
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4712022/
Naturally occurring cholesterol analogues in LNP
https://www.nature.com/articles/s41467-020-14527-2
Mechanisms for DVT & Management
https://cdt.amegroups.com/article/view/16872/18087#:~:text=Virchow's%20Triad%2C%20first%20described%20in,cause%20thrombus%20formation%20(8)
Plasma lipids & Clotting
https://onlinelibrary.wiley.com/doi/full/10.1002/rth2.12017
Shot may trigger thyroid autoimmunity
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9277984/
Phosphatidylethanolamine
https://www.ahajournals.org/doi/full/10.1161/atvb.21.10.1695
https://assets.researchsquare.com/files/rs-2330137/v1/23983117-21bc-479d-89ba-d18194c5629a.pdf?c=1670257161
Clotting and lipids
https://onlinelibrary.wiley.com/doi/full/10.1002/rth2.12017
Endothelial cell dysfunction
https://www.nature.com/articles/s41401-022-00998-0#:~:text=SARS-CoV-2%20or%20viral,activity%20and%20multi-organ%20injury
-
1:16:37
The Open Forum Podcast
1 year ago030 Attack on the USS Liberty - When Israel attacked the US Military | Phil Tourney
2614 -
1:23:11
Timcast
2 hours agoTrump SLAMS Anti-American Museums, BANS Migrants For WOKE Views
87.3K48 -
5:46
Buddy Brown
1 day ago $0.19 earnedOklahoma Just Made the BOLDEST MOVE of our Time! | Buddy Brown
9.23K7 -
2:01:04
Steven Crowder
4 hours agoThe Gavin Newsom 2028 Campaign Begins... And It Sucks
260K182 -
11:25
Mike Rowe
1 day agoThe Funniest Mashup You've Ever Seen With My Mom, Peggy Rowe | Coffee With Mom
21.7K10 -
1:23:33
Steve-O's Wild Ride! Podcast
6 days ago $13.78 earnedRainn Wilson and Steve-O Break The Silence On Their Long Friendship | Wild Ride #263
52.9K30 -
1:00:17
VINCE
5 hours agoThe Trump Admin Isn't Having This... | Episode 107 - 08/20/25
203K126 -
LIVE
JuicyJohns
5 hours ago $1.84 earned🟢#1 REBIRTH PLAYER 10.2+ KD🟢
372 watching -
1:45:07
Dear America
5 hours agoAndrew Bailey is now Bongino’s CO-DEPUTY DIRECTOR of the FBI!! Is Bongino On His Way Out??
116K70 -
3:18:47
Reidboyy
4 hours ago $0.35 earnedNEW FREE FPS OUT ON CONSOLE TODAY! (Delta Force = BF6 with Killstreaks)
18.2K1