San Francisco 49ers vs Los Angeles Chargers Predictions and Odds | Sunday Night Football Preview

San Francisco 49ers vs Los Angeles Chargers betting picks, predictions and odds for their NFL Week 10 showdown in Santa Clara. Direct from Las Vegas, our panel of professional sports handicappers look at the Vegas odds and offer their expert NFL analysis on this Sunday Night Football clash between the Chargers and 49ers. At the time of posting, the WagerTalk Live Odds screen is showing San Francisco as a 7-point home favorite over the visitors from Los Angeles, with the over/under sitting at 45.5 points.

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