New Research: Is muscle weakness the new smoking?

A new study out of the University of Michigan has shown that one strength marker, if not optimal, has a clear link with faster biological aging.
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Links:

Flex Bar Video: https://www.youtube.com/watch?v=Jkl5X4qOP70

https://onlinelibrary.wiley.com/doi/10.1002/jcsm.13110
https://www.researchgate.net/figure/Association-between-grip-strength-and-DNA-methylation-age-acceleration-in-the-total-group_fig1_324224736
https://www.ajmc.com/view/what-we-re-reading-climate-resilience-pledge-improving-addiction-care-weak-grip-strength-may-signal-biological-aging

Everyone ages at a different pace, birthdays may be the same, but bodies will be different. That's why two 50-year-olds, despite having lived the same number of years, will probably have different biological or epigenetic ages - meaning that a host of intrinsic and extrinsic factors will have caused them to age at varying paces, with different levels of risk for disease and possibly even an early death.
Lifestyle choices, such as diet, smoking, sleep and exercise all contribute to accelerating your biological age beyond your chronological age; your birthday age. In other words, your body is aging faster than expected. And for the first time, researchers have found that muscle weakness marked by grip strength, a proxy for overall strength capacity, is associated with accelerated biological age. Specifically, the weaker your grip strength, the older your biological age, according to results published in the Journal of Cachexia (Ka-keks-ia), Sarcopenia and Muscle. Researchers at Michigan Medicine modeled the relationship between the biological age and the grip strength, this was done with 1,274 middle aged and older adults.
They used 3 "age acceleration clocks" based on DNA methylation, a process that provides a molecular biomarker and estimator of the pace of aging. The clocks were originally modeled from various studies examining diabetes, cardiovascular disease, cancer, physical disability, Alzheimer's disease, inflammation and early mortality.
The results clearly revealed that both older men and women showed a marked association between lower grip strength, and biological age acceleration, across all the DNA methylation clocks.
Mark Peterson, PhD, the lead author and Associate Professor of Physical Medicine & Rehabilitation at the University of Michigan said "We've known that muscular strength is a predictor of longevity, and that weakness is a powerful indicator of disease and mortality, but for the first time, we have found strong evidence of a biological link between muscle weakness and actual acceleration in biological age. This suggests that if you maintain your muscle strength across the lifespan, you may be able to protect against many common age-related diseases.
We know that smoking, for example, can be a powerful predictor of disease and mortality, but now we know that muscle weakness could be the new smoking."
Past studies have shown that low grip strength is an extremely strong predictor of adverse health events. One study found that it is a better predictor of cardiovascular events.
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