2022 Research | Latest Human NMN Study Results - JUST THE FACTS!

A research team from the Tsukuba University in Japan published their NMN study findings in the Nutrients; Nutrients is a peer-reviewed, open access journal of human nutrition.

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My Current Anti-Aging Protocol:
• 1.5 grams of NMN
• 1.5 grams of Trans-resveratrol
• 1.5 grams of Berberine
• 2 grams of TM
• 5,000 IU (International Units) of vitamin D3
• 120 mcg (micrograms) of vitamin K2 (Mk 7)
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• 200mg high molecular weight hyaluronic acid
• 2,400mg of Fisetin a day, but only on the 1st, 2nd and 3rd of each month
• 2,400mg of Quercetin a day, but only on the 1st, 2nd and 3rd of each month

https://www.mdpi.com/2072-6643/14/4/755
https://pubmed.ncbi.nlm.nih.gov/35215405/
https://www.researchgate.net/publication/358559751_Effect_of_12-Week_Intake_of_Nicotinamide_Mononucleotide_on_Sleep_Quality_Fatigue_and_Physical_Performance_in_Older_Japanese_Adults_A_Randomized_Double-Blind_Placebo-Controlled_Study

A research team from the Tsukuba University in Japan published their NMN study findings in the Nutrients; Nutrients is a peer-reviewed, open access journal of human nutrition.  

As we age, our sleep quality dissipates, facilitating cognitive decline and ultimately, depressive moods and states of mind. The resulting depression and diminished cognition may lead to a snowball effect of falling out of shape whilst also becoming frail. Age-associated frailty further increases the probability of falls, and diseases, such as metabolic disorders and cardiovascular ailments.
 
The research team compared the effects of taking 250 mgs of NMN daily, in either the morning or in afternoon, this study was conducted over a 12-week period. Study participants were aged 65 and older, and those using too much caffeine, having too much stress, and/or taking sleeping medication or anti-depressants were excluded from the study. After applying these exclusion criteria, the 108 participants were split into four groups of 27 as follows; An NMN morning group, An NMN afternoon group, And two corresponding placebo groups.
To find out whether supplementing with NMN improves sleep quality, the team used the Pittsburgh Sleep Quality Index (PSQI), some of you may remember this was also used in the Japanese safety trial. This analytical tool has been proven reliable in measuring subjective sleep quality by examining sleep duration, sleep disturbance, daytime dysfunction, sleep quality, and sleep efficiency. The results showed that afternoon NMN improves sleep duration and quality, as shown by a lower sleep disturbance score, feel free to pause the video to check the numbers.

To then find out whether NMN supplementation during the afternoon also improved the overall quality of life, the Japan-based research team measured indices of fatigue. They found that drowsiness significantly decreased along with mental dullness and total fatigue. Reductions in drowsiness and fatigue can enhance concentration, and the capability to perform cognitive tasks
 
Improvements in sleep also positively affected measurements of physical function for the afternoon NMN group. For example, a physical fitness test showed that the duration from sitting to standing, consecutively for 5 times improved significantly when NMN was administered in the afternoon. The timed up and go exercise improved substantially too. This data may show that NMN in the afternoon improves overall sleep and physical function, which may positively impact mood and diminish potential age-related depression. 

So, taking NMN in the afternoon appears to significantly improve sleep, reduced drowsiness, and improve some performance of physical tasks. These types of improvements may also impact a person’s day-to-day attitude, which may then improve one’s quality of life and may extend the number of years that they live in overall good health, we know this as healthspan.

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