cas: 210821-63-9 Org12962 HCl hydrochloride Org-12962

cas: 210821-63-9 Org12962 HCl hydrochloride Org-12962

CBNumber: CB02473321

Chemical Name: Org 12962 HCl

Molecular Formula: C10H11ClF3N3.ClH

Formula Weight: 302.126

CAS No.: 210821-63-9

ORG-12962 is a pyridinylpiperazine drug developed by Organon, which acts as a potent and selective agonist for the 5-HT2 receptor family, with highest affinity at 5-HT2C and lowest at 5-HT2B subtypes. It was developed as a potential anti-anxiety drug, but was discontinued from human trials after tests in a public speaking challenge showed that its anti-anxiety effects were accompanied by side effects such as dizziness and a "spacey" feeling, which were attributed to poor selectivity in vivo over the hallucinogenic 5-HT2A receptor.