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Campbell is involved with several charitable causes. She supports the Nelson Mandela Children's Fund, for which she organised a benefit Versace fashion show in 1998.[10] Held at Nelson Mandela's South African presidential residence,[10] the show was the subject of a documentary titled FashionKingdom, or alternatively, Naomi Conquers Africa. Campbell, whose mother has battled breast cancer, also supports Breakthrough Breast Cancer.[53] In 2004, she was featured on FHM's charity single Do Ya Think I'm Sexy?, as well as in the accompanying music video, of which all profits were donated to Breakthrough.[54] She appeared in a print and media campaign for the charity's fundraising initiative Fashion Targets Breast Cancer,[55] and she opened a Breakthrough breast cancer research unit in 2009.[56]

Campbell at the 2008 Cannes Film Festival
In 2005, Campbell founded the charity We Love Brazil, which aims to raise awareness and funds to fight poverty in Brazil through the sale of fabrics made by local women.[57] That same year, Campbell founded the charity Fashion for Relief, which has organised fund-raising fashion shows to benefit victims of Hurricane Katrina in 2005, the Mumbai terrorist attacks in 2008, the Haiti earthquake in 2010, the Japan earthquake in 2011, and the Syrian refugee crisis in 2017.[58][10][59] By 2011, Fashion for Relief had reportedly raised £4.5 million.[59] In 2018 Campbell held another Relief charity gala and the theme was Race To Equality.[60]