Long Story Short Episode 33: Methylene Blue and Near Infrared Light for Neuroprotection

Studies show that neurons are metabolically protected when low dose Methylene Blue is administered systemically. Methylene Blue promotes energy metabolism and neuronal survival. A similar protective effect is observed with near infrared light. Let's review.

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References
URL list from Thursday, Nov. 10 2022

Frontiers | Protection against neurodegeneration with low-dose methylene blue and near-infrared light
https://www.frontiersin.org/articles/10.3389/fncel.2015.00179/full

Methylene Blue Reduces Acute Cerebral Ischemic Injury via the Induction of Mitophagy | Molecular Medicine | Full Text
https://molmed.biomedcentral.com/articles/10.2119/molmed.2015.00038

Effect of Methylene Blue on White Matter Injury after Ischemic Stroke - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7872771/

Repurposing methylene blue in the management of COVID-19: Mechanistic aspects and clinical investigations - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8352658/

Frontiers | Methylene Blue Reduces Neuronal Apoptosis and Improves Blood-Brain Barrier Integrity After Traumatic Brain Injury
https://www.frontiersin.org/articles/10.3389/fneur.2019.01133/full

Addressing Personal Protective Equipment (PPE) Decontamination: Methylene Blue and Light Inactivates SARS-CoV-2 on N95 Respirators and Masks with Maintenance of Integrity and Fit | medRxiv
https://www.medrxiv.org/content/10.1101/2020.12.11.20236919v2.full

Mitochondria as a target for neuroprotection: role of methylene blue and photobiomodulation
https://translationalneurodegeneration.biomedcentral.com/articles/10.1186/s40035-020-00197-z

Photobiomodulation as a treatment for neurodegenerative disorders: current and future trends - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6694374/

Shining light on the head: Photobiomodulation for brain disorders - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066074/

Nitric Oxide, Cytochrome C Oxidase, and the Cellular Response to Hypoxia | Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.ahajournals.org/doi/10.1161/ATVBAHA.108.181628

Mitochondrial electron transport chain, ROS generation and uncoupling (Review)
https://www.spandidos-publications.com/10.3892/ijmm.2019.4188#:~:text=The%20sites%20of%20ROS%20production,peroxide%20(48%2C49).

Frontiers | Mitochondrial Reactive Oxygen Species and Their Contribution in Chronic Kidney Disease Progression Through Oxidative Stress
https://www.frontiersin.org/articles/10.3389/fphys.2021.627837/full#:~:text=Mitochondrial%20reactive%20oxygen%20species%20are,et%20al.%2C%202013).

Mitochondria—Fundamental to Life and Health - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4684129/

After Treatment with Methylene Blue is Effective against Delayed Encephalopathy after Acute Carbon Monoxide Poisoning - PubMed
https://pubmed.ncbi.nlm.nih.gov/29151273/

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This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only. Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
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