After the U.S. Department of Defense

conducted an analysis
Jack and Valerie stole the tactical nukes that Kriegel used to destroy the crime of genetic modification experiments. Jack expressed unease about the use of nuclear weapons, but Valerie assured him, "This tactical nuke, just enough to destroy the plant and the base. Before it explodes, we will leave the mountains along a headwind". Before entering the plant, Doyle warns that substances that induce mutations in organisms during the explosion could contaminate them, advises them to use an antidote before setting up the nuke, and at the plant, he instructs them to remove the immune serum from a red box with a biohazard symbol and inject it. They did so. After setting the nuke Valerie and Jack leave the plant, the nuke explodes and they lose consciousness.