1 year ago

"SARSCOV-2 的基因組包含獨特的限制性內切酶識別位點的特殊模式，允許
合成病毒的病毒基因組特徵的有效分解和重新組裝。在這裡，我們報告在沒有感染史的冠狀病毒中觀察到這種模式的可能性生物工程。我們發現 SARS-CoV-2 是一種異常，更可能是合成產物基因組組裝比自然進化。 SARS-CoV-2 的限制性圖譜與許多先前報導的合成冠狀病毒基因組符合有效的反向遺傳系統，與近親的差異顯著更高。這些看起來像合成的識別位點中的同義突變，並且具有合成的指紋不太可能是從它的近親進化而來。"

"To prevent future pandemics, it is important that we understand whether SARS-CoV-2 spilled over directly from animals to people, or indirectly in a laboratory accident. The genome of SARS-COV-2 contains a peculiar pattern of unique restriction endonuclease recognition sites allowing efficient dis- and re-assembly of the viral genome characteristic of synthetic viruses. Here, we report the likelihood of observing such a pattern in coronaviruses with no history of bioengineering. We find that SARS-CoV-2 is an anomaly, more likely a product of synthetic genome assembly than natural evolution. The restriction map of SARS-CoV-2 is consistent with many previously reported synthetic coronavirus genomes, meets all the criteria required for an efficient reverse genetic system, differs from closest relatives by a significantly higher rate of synonymous mutations in these synthetic-looking recognitions sites, and has a synthetic fingerprint unlikely to have evolved from its close relatives. We report a high likelihood that SARS-CoV-2 may have originated as an infectious clone assembled in vitro. "

https://www.biorxiv.org/content/10.1101/2022.10.18.512756v1.full.pdf

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