Peyronie’s Disease and The Autoimmune System | ShockWave Therapy for Peyronie's Disease

An autoimmune disease is a condition in which your immune system mistakenly attacks your body. The immune system normally guards against germs like bacteria and viruses. When it senses these foreign invaders, it sends out an army of fighter cells to attack them. Learn more at https://www.peyroniesdisease.co.uk

Men suffering an autoimmune disease are highly co-morbid to having Peyronie’s disease. An autoimmune disease is a condition in which your immune system attacks healthy cells by mistake.

In normal situations, the immune system is the body’s way of protecting itself from infection and it can tell the difference between good and foreign cells but with an autoimmune disease, a series of fighter cells attack the good cells. It releases proteins called autoantibodies that attack the healthy cells.

There are more than 80 autoimmune diseases, some like type 1 diabetes attack just one organ: the pancreas, whereas others like Systemic Lupus Erythematosus, attack the whole body.

Men who have an autoimmune disease are vulnerable to developing Peyronie’s disease if the immune system should mistakenly attack the healthy cells within the penis. This can lead to inflammation in the penis and can cause scarring.

Abstract
Introduction: Although heavily investigated over the last decades, Peyronie's disease (PD) pathogenesis remains unclear.

Aim: We sought to investigate the association between PD and autoimmune diseases (ADs) in men seeking medical help for sexual dysfunction in the real-life setting.

Methods: Complete sociodemographic and clinical data from a homogenous cohort of 1,140 consecutive Caucasian-European men were analyzed. Health-significant comorbidities were scored with the Charlson Comorbidity Index and ADs were stratified according to International Classification of Diseases, Ninth Revision classification.

Main outcome measures: Descriptive statistics and multivariate logistic regression models tested the association between ADs and PD.

Conclusions: Our observational findings showed that ADs are highly comorbid with PD in a large cohort of same-race individuals seeking medical help for sexual dysfunction in the real-life setting.

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