1 year ago

A new study has looked into our recovery from stress as a marker of longevity and how it is combined with DNA methylation clocks to give a more accurate biological age.
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Recently, scientists have reported the first promising examples of biological age reversal through experimental interventions.
Indeed, many biological clock types properly predict more years of life for those who choose healthy lifestyles or quit unhealthy ones, such as poor diet, smoking and lack of exercise. But, still unknown is how quickly biological age is changing over time for the same individual, and distinguishing between the transient fluctuations and the genuine bio-age change trend.
This is one of the reasons I have blood tests every 3 months, and then use those tests to predict my biological age; 4 times a year as opposed to once will give more reliable data.
The team of experts in biology and biophysics presented results of a detailed analysis of dynamic properties and the fluctuations of physiological indices along individual aging trajectories.
Healthy human subjects turned are very resilient, whereas the loss of resilience turned out to be related to chronic diseases and elevated all-cause mortality risks.
The rate of recovery to the baseline levels after stresses, was found to deteriorate with age.
Accordingly, the time needed to recover was getting longer and longer; around 2 weeks for 40-year-old healthy adults, and up to 6 weeks for 80-year-olds.
Tim Pyrkov, first author and head of the mHealth project at Gero said
"Calculation of resilience based on physical activity data streams has been implemented in the GeroSense iPhone app and made available for the research community via web-based API."
If the trend holds at later ages, the extrapolation shows a complete loss of human body resilience at around 120 to 150 years of age.
• The reduced resilience was observed even in individuals not suffering from major chronic disease.
As we age, more time is required to recover from anxiety, and as a result we spend less and less time close to our optimal physiological state.
• The predicted loss of resilience even in the healthiest, most successfully aging individuals, might explain why we do not see an evidential increase of maximum lifespan, while the average lifespan has steadily grown over recent decades.
Aging in humans is a complex, multi-stage process.
• It would, therefore, be difficult to compress the aging process into a single number, such as biological age.
• Gero's work shows that longitudinal studies open a whole new window on the aging process and produce independent biomarkers of human aging, suitable for applications in gero-science and future clinical trials of anti-aging interventions.
Peter Fedichev, the co-founder and CEO of Gero said "Aging in humans exhibits universal features common to complex systems operating on the brink of disintegration. This work is a demonstration of how concepts borrowed from physical sciences can be used in biology to probe different aspects of senescence and frailty to produce strong interventions against aging."
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