1 year ago

A study published by the University of California has shown a clear link between accelerated epigenetic aging and the chances of reaching the age of 90.
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In this first-of-its-kind study of 1,813 older women It is suggested that the accelerated biological aging of the body, and epigenetic age acceleration specifically, is associated with lower odds of living to be 90 years old, and also being physically mobile and having intact mental function.
In the July 2022 online edition of the JAMA Network Open, a multi-institutional team of researchers led by the Herbert Wertheim School of Public Health and Human Longevity Science at University of California San Diego reported that - epigenetic age acceleration could be used as a biomarker for healthy longevity and to estimate functional and cognitive aging.
Professor Andrea LaCroix PhD said "Older people know well that age is just a number that may not be indicative of their health status.
What if we had a way to measure how fast we were aging that could predict our odds of living a long and healthy life?
In aging research, we call this an individual's healthspan."
What is Chronological age and Biological age?

• Chronological age is based on a person's birthdate, or as David Sinclair puts it ‘the number of times the earth has gone around our Sun.’ – Not really a relevant health marker when it comes to our health.

• Epigenetic age refers to the biological age of a person's cells, tissues and organ systems.

• If an individual's epigenetic age is greater than their chronological age, the person is undergoing epigenetic age acceleration, which is associated with higher risk of cancer, cardiovascular disease, Parkinson's disease and other age related dies diseases such as sarcopenia.
Based on four different epigenetic "clocks" that measure biological aging, the findings were:
• Every 5 to 8 years of epigenetic age acceleration was associated with 20% to 32% lower odds of living to age 90 (that’s longevity) and with intact mobility and cognitive function (known as Healthspan).
Dr. LaCroix said "Healthspan is important because the number of individuals who will live to be 90 years and older will quadruple from 1.9 million in 2016 – To 7.6 million in 2050 in the United States alone."

Buying DNA Methylation tests? There are many companies that now offer this service, but it is important to check how many DNA markers each company tests against, the more markers; the more accurate your epigenetic age result. There are companies such as Chronomics that test against millions of markers that are accurate to within 1 year. And there are companies like ep-age.com that measure against less than 20 individual markers, and can be as far out as 5 to 10 years. I would avoid this company and any company that isn’t measuring against at least hundreds of thousands of markers. doNotAge use the Chronomics Age test that is accurate to within 1 year, and is you use the code ‘MYNMN’ you can 10% off the price at the checkout
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